| Gene Symbol |
SNW1
|
| Entrez Gene |
22938
|
| Alt Symbol |
Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SNW domain containing 1
|
| Other Description |
SKI interacting protein|SKI-interacting protein|SNW domain-containing protein 1|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator NCoA-62|nuclear receptor coactivator, 62-kD
|
| Swissprots |
Q5D0D6 Q13483 A8K8A9 Q13573 Q32N03
|
| Accessions |
AAB48857 AAF01479 AAF23325 EAW81305 EAW81306 EAW81307 EAW81308 Q13573 AF045184 AAC31697 AK292274 BAF84963 AK293619 BAG57078 AK302246 BAG63598 AK316087 BAH14458 AX775981 CAE11690 BC032377 BC040112 AAH40112 BC046105 AAH46105 BC065286 AAH65286 BC105585 AAI05586 BC108902 BC108903 AAI08904 BT020060 AAV38863 BT020061 AAV38864 CR457433 CAG33714 U51432 AAC15912 XM_005267413 XP_005267470 XM_005267414 XP_005267471 NM_012245 NP_036377
|
| Function |
Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to t
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12840015}.
|
| Top Pathways |
Notch signaling pathway, Spliceosome, Viral carcinogenesis, Epstein-Barr virus infection
|