SNW1
| Gene Symbol | SNW1 |
|---|---|
| Entrez Gene | 22938 |
| Alt Symbol | Bx42, NCOA-62, PRPF45, Prp45, SKIIP, SKIP |
| Species | Human |
| Gene Type | protein-coding |
| Description | SNW domain containing 1 |
| Other Description | SKI interacting protein|SKI-interacting protein|SNW domain-containing protein 1|homolog of Drosophila BX42|nuclear protein SkiP|nuclear receptor coactivator NCoA-62|nuclear receptor coactivator, 62-kD |
| Swissprots | Q5D0D6 Q13483 A8K8A9 Q13573 Q32N03 |
| Accessions | AAB48857 AAF01479 AAF23325 EAW81305 EAW81306 EAW81307 EAW81308 Q13573 AF045184 AAC31697 AK292274 BAF84963 AK293619 BAG57078 AK302246 BAG63598 AK316087 BAH14458 AX775981 CAE11690 BC032377 BC040112 AAH40112 BC046105 AAH46105 BC065286 AAH65286 BC105585 AAI05586 BC108902 BC108903 AAI08904 BT020060 AAV38863 BT020061 AAV38864 CR457433 CAG33714 U51432 AAC15912 XM_005267413 XP_005267470 XM_005267414 XP_005267471 NM_012245 NP_036377 |
| Function | Involved in transcriptional regulation. Modulates TGF- beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1- mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to t |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12840015}. |
| Top Pathways | Notch signaling pathway, Spliceosome, Viral carcinogenesis, Epstein-Barr virus infection |
Skip CRISPR/Cas9 KO Plasmid (h) - sc-403370 from Santa Cruz Biotechnology
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Skip HDR Plasmid (h) - sc-403370-HDR from Santa Cruz Biotechnology
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Skip Double Nickase Plasmid (h) - sc-403370-NIC from Santa Cruz Biotechnology
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Skip Double Nickase Plasmid (h2) - sc-403370-NIC-2 from Santa Cruz Biotechnology
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Skip CRISPR Activation Plasmid (h) - sc-403370-ACT from Santa Cruz Biotechnology
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Skip CRISPR Activation Plasmid (h2) - sc-403370-ACT-2 from Santa Cruz Biotechnology
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Skip Lentiviral Activation Particles (h) - sc-403370-LAC from Santa Cruz Biotechnology
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Skip Lentiviral Activation Particles (h2) - sc-403370-LAC-2 from Santa Cruz Biotechnology
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Skip siRNA (h) - sc-37164 from Santa Cruz Biotechnology
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Skip shRNA Plasmid (h) - sc-37164-SH from Santa Cruz Biotechnology
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Skip shRNA (h) Lentiviral Particles - sc-37164-V from Santa Cruz Biotechnology
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SNW1 RNAi - H00022938-R01 from Novus Biologicals
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MISSION® esiRNA - EHU107711 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20286 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20286 from Sigma-Aldrich
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SNW1 siRNA (Human) - CRH7888 from Cohesion Biosciences
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SNW1 - MBS8240412 from MyBioSource
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shRNA set against Human SNW1 (NM_012245.2) - SHH414536 from Creative biogene
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shRNA set against Human SNW1(NM_012245.2) - SHL023022 from Creative biogene
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SNW1 shRNA Plasmid (Human) - CHH7888 from Cohesion Biosciences
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SNW1 miRNA 3'UTR clone - MiUTR1H-09709 from Creative biogene
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