PDE11A

Gene Symbol PDE11A
Entrez Gene 50940
Alt Symbol PPNAD2
Species Human
Gene Type protein-coding
Description phosphodiesterase 11A
Other Description cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Swissprots Q9HCR9 Q9GZY7 Q14CD1 Q96S76 Q53T16 Q9NY45 Q9HB46
Accessions AAX93113 AAY14803 AAY24130 BAB62712 BAB62713 BAB62714 EAX11047 EAX11048 EAX11049 EAX11050 EAX11051 Q9HCR9 AB036704 BAB16371 AB038041 BAB16372 AF281865 AAG32023 AI919276 AJ251509 CAB82573 AJ278682 CAC15567 AK074273 AK127194 AK294076 BAG57418 AK309155 BC112393 AAI12394 BC114431 AAI14432 BX105579 BX649056 HM771389 HM771390 ADV69110 HM771391 ADV69111 NM_001077196 NP_001070664 NM_001077197 NP_001070665 NM_001077358 NP_001070826 NM_016953 NP_058649
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}.
Subcellular Location Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
Tissue Specificity Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}.
Top Pathways Morphine addiction, Purine metabolism

PDE11A (B-7) - sc-365655 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PDE11A (B-7): sc-365655. Western blot analysis of PDE11A expression in PC-3 whole cell lysate.

PDE11A (C-17) - sc-82306 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PDE11A (H-178) - sc-98557 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PDE11A (H-178): sc-98557. Western blot analysis of PDE11A expression in Hep G2 whole cell lysate.

Anti-PDE11A antibody - ab14624 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE11A antibody - ab115624 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115624, at 10 µg/ml, staining PDE11A in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry. Following primary incubation slides were incubated with biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-PDE11A antibody - ab154273 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PDE11A antibody (ab154273) at 1/1000 dilution + PC-3 whole cell lysate at 30 µg

Anti-PDE11A antibody - ab62832 from Abcam

Prices $370.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-PDE11A antibody (ab62832) at 1 µg/ml + Human Prostate lysate at 35 µgObserved band size : 65 kDa (why is the actual band size different from the predicted?)

Anti-PDE11A antibody - ab116556 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE11A antibody (ab116556) at 1/100 dilution + Mouse stomach tissue lysate at 35 µg

Anti-PDE11A antibody - ab61822 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab61822, at 5µg/ml, staining human PDE11A in testis by immunohistochemistry. Formalin-fixed paraffin-embedded tissue.

Anti-PDE11A4 antibody - ab14674 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (C-Terminus) - LS-C82353 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, APC) - LS-C216660 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, Biotin) - LS-C216661 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, AP) - LS-C216659 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, FITC) - LS-C216662 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, Azide-free, HRP) - LS-C216664 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63) - LS-C323883 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa33-63, PE) - LS-C216663 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PDE11A Antibody (aa114-163) - LS-C151612 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE11A antibody Western Blot of U937.

Anti-PDE11A Antibody (aa390-439) - LS-C151613 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PDE11A antibody Western Blot of HeLa.

Anti-PDE11A Antibody (aa34-63) - LS-C163465 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PDE11A Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon tissue followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-PDE11A Antibody (Internal) IHC-plus™ - LS-A746 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-PDE11A antibody LS-A746 IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-PDE11A Antibody (aa455-468) IHC-plus™ - LS-B2676 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-PDE11A antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2676 concentration 10 ug/ml.

PDE11A Antibody - NBP1-32910 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE11A Antibody [NBP1-32910] - Sample (30 ug of whole cell lysate) A: Hep G2 5% SDS PAGE; antibody diluted at 1:5000.

PDE11A Antibody - NBP1-85919 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PDE11A Antibody [NBP1-85919] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells) Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells)
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