PDE11A

Gene Symbol	PDE11A
Entrez Gene	50940
Alt Symbol	PPNAD2
Species	Human
Gene Type	protein-coding
Description	phosphodiesterase 11A
Other Description	cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Swissprots	Q9HCR9 Q9GZY7 Q14CD1 Q96S76 Q53T16 Q9NY45 Q9HB46
Accessions	AAX93113 AAY14803 AAY24130 BAB62712 BAB62713 BAB62714 EAX11047 EAX11048 EAX11049 EAX11050 EAX11051 Q9HCR9 AB036704 BAB16371 AB038041 BAB16372 AF281865 AAG32023 AI919276 AJ251509 CAB82573 AJ278682 CAC15567 AK074273 AK127194 AK294076 BAG57418 AK309155 BC112393 AAI12394 BC114431 AAI14432 BX105579 BX649056 HM771389 HM771390 ADV69110 HM771391 ADV69111 NM_001077196 NP_001070664 NM_001077197 NP_001070665 NM_001077358 NP_001070826 NM_016953 NP_058649
Function	Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}.
Subcellular Location	Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
Tissue Specificity	Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}.
Top Pathways	Morphine addiction, Purine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDE11A Antibody Blocking Peptide - LS-E2878 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE11A Antibody Blocking Peptide - LS-E23362 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE11A Antibody Blocking Peptide - LS-E23363 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE11A Antibody Blocking Peptide - LS-E26404 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDE11A-Antibody-N-term-Blocking-peptide - BP14002a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PDE11A blocking peptide - GTX89018-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

PDE11A Peptide - AC21-1243-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

PDE11A Control Peptide - AP10259CP-N from Acris Antibodies Category Peptide Prices $255.00 Sizes 100 µg

PDE11A control peptide - AP10260CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PDE11A control peptide - AP10261CP-N from Acris Antibodies Category Peptide Prices $235.00 Sizes 100 µg

PDE11A Peptide - 46-150P from ProSci Category Peptide Species Human

PDE11A fusion protein - ag16504 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

PDE11A fusion protein - Ag16495 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PDE11A4, Active Human Recombinant Protein - GWB-11830F from Genway Biotech Category Protein Prices $600.00 Sizes 10 µg Species Human

Recombinant Human Phosphodiesterase 11A, GST-tagged - PDE11A-441H from Creative Biomart Category Protein Source Sf9 cell.

Recombinant Human Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A(PDE11A) , - CSB-YP875726HU CSB-EP875726HU CSB-BP875726HU CSB-MP875726HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PDE11A (transcript variant 4) - TP320304 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Phosphodiesterase 11A4, Recombinant Protein - MBS638215 from MyBioSource Category Protein Prices $715.00 Sizes 10 µg Source Sf9 insect cells

PDE11A, Peptide - MBS425496 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

PDE11A Recombinant Protein Antigen - NBP1-85919PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PDE11A Peptide, Human - M34GP11495H from Creative Peptides Category Peptide Source Synthetic. Species Human

Dual 3',5'-cyclic-AMP and-GMP phosphodiesterase 11A (PDE11A), partial, Recombinant Protein - MBS1365229 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PDE11A Immunizing peptide - orb16854 from Biorbyt Category Peptide

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