| Gene Symbol | PDE11A |
|---|---|
| Entrez Gene | 50940 |
| Alt Symbol | PPNAD2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphodiesterase 11A |
| Other Description | cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A |
| Swissprots | Q9HCR9 Q9GZY7 Q14CD1 Q96S76 Q53T16 Q9NY45 Q9HB46 |
| Accessions | AAX93113 AAY14803 AAY24130 BAB62712 BAB62713 BAB62714 EAX11047 EAX11048 EAX11049 EAX11050 EAX11051 Q9HCR9 AB036704 BAB16371 AB038041 BAB16372 AF281865 AAG32023 AI919276 AJ251509 CAB82573 AJ278682 CAC15567 AK074273 AK127194 AK294076 BAG57418 AK309155 BC112393 AAI12394 BC114431 AAI14432 BX105579 BX649056 HM771389 HM771390 ADV69110 HM771391 ADV69111 NM_001077196 NP_001070664 NM_001077197 NP_001070665 NM_001077358 NP_001070826 NM_016953 NP_058649 |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}. |
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}. |
| Top Pathways | Morphine addiction, Purine metabolism |
PDE11A CRISPR/Cas9 KO Plasmid (h) - sc-408047 from Santa Cruz Biotechnology
|
||||||||
PDE11A HDR Plasmid (h) - sc-408047-HDR from Santa Cruz Biotechnology
|
||||||||
PDE11A Double Nickase Plasmid (h) - sc-408047-NIC from Santa Cruz Biotechnology
|
||||||||
PDE11A Double Nickase Plasmid (h2) - sc-408047-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PDE11A CRISPR Activation Plasmid (h) - sc-408047-ACT from Santa Cruz Biotechnology
|
||||||||
PDE11A CRISPR Activation Plasmid (h2) - sc-408047-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PDE11A Lentiviral Activation Particles (h) - sc-408047-LAC from Santa Cruz Biotechnology
|
||||||||
PDE11A Lentiviral Activation Particles (h2) - sc-408047-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PDE11A siRNA (h) - sc-76095 from Santa Cruz Biotechnology
|
||||||||
PDE11A shRNA Plasmid (h) - sc-76095-SH from Santa Cruz Biotechnology
|
||||||||
PDE11A shRNA (h) Lentiviral Particles - sc-76095-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU084731 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1894 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1894 from Sigma-Aldrich
|
||||||||
PDE11A siRNA (Human) - CRH9436 from Cohesion Biosciences
|
||||||||
shRNA set against Human PDE11A (NM_016953.3) - SHH372332 from Creative biogene
|
||||||||
shRNA set against Human PDE11A(NM_001077197.1) - SHR099232 from Creative biogene
|
||||||||
shRNA set against Human PDE11A(NM_001077358.1) - SHR099250 from Creative biogene
|
||||||||
shRNA set against Human PDE11A(NM_001077196.1) - SHR099444 from Creative biogene
|
||||||||
shRNA set against Human PDE11A(NM_001077358.1) - SHR099480 from Creative biogene
|
||||||||
shRNA set against Human PDE11A(NM_016953.3) - SHR099492 from Creative biogene
|
||||||||
Human PDE11A siRNA - orb269938 from Biorbyt
|
||||||||
PDE11A shRNA Plasmid (Human) - CHH9436 from Cohesion Biosciences
|
||||||||
PDE11A miRNA 3'UTR clone - MiUTR1H-07701 from Creative biogene
|
||||||||
PDE11A miRNA 3'UTR clone - MiUTR1H-07702 from Creative biogene
|