| Gene Symbol |
PDE11A
|
| Entrez Gene |
50940
|
| Alt Symbol |
PPNAD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 11A
|
| Other Description |
cAMP and cGMP cyclic nucleotide phosphodiesterase 11A|dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
|
| Swissprots |
Q9HCR9 Q9GZY7 Q14CD1 Q96S76 Q53T16 Q9NY45 Q9HB46
|
| Accessions |
AAX93113 AAY14803 AAY24130 BAB62712 BAB62713 BAB62714 EAX11047 EAX11048 EAX11049 EAX11050 EAX11051 Q9HCR9 AB036704 BAB16371 AB038041 BAB16372 AF281865 AAG32023 AI919276 AJ251509 CAB82573 AJ278682 CAC15567 AK074273 AK127194 AK294076 BAG57418 AK309155 BC112393 AAI12394 BC114431 AAI14432 BX105579 BX649056 HM771389 HM771390 ADV69110 HM771391 ADV69111 NM_001077196 NP_001070664 NM_001077197 NP_001070665 NM_001077358 NP_001070826 NM_016953 NP_058649
|
| Function |
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'- GMP, respectively. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
|
| Tissue Specificity |
Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11121118, ECO:0000269|PubMed:15800651, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16767104}.
|
| Top Pathways |
Morphine addiction, Purine metabolism
|