Gene Symbol | Endov |
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Entrez Gene | 338371 |
Alt Symbol | A730011L01Rik |
Species | Mouse |
Gene Type | protein-coding |
Description | endonuclease V |
Other Description | novel endonuclease V protein|putative endonuclease FLJ39025 homolog |
Swissprots | Q3TCQ4 Q8C9A2 B1ATE4 Q8C3Y1 |
Accessions | EDL34708 EDL34709 EDL34710 Q8C9A2 AK042626 BAC31310 AK084233 AK084548 BAC39216 AK170595 BAE41901 AK172181 BAE42869 AK179832 AK183732 AK209873 BC056486 AAH56486 BY266398 XM_006533589 XP_006533652 XM_011249087 XP_011247389 XR_388482 XR_879709 XR_879710 NM_001164636 NP_001158108 NM_177394 NP_796368 |
Function | Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm. Nucleus, nucleolus. |
Tissue Specificity | Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain. {ECO:0000269|PubMed:12853604}. |
Anti-ENDOV Antibody - LS-C307562 from LifeSpan Bioscience
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Anti-ENDOV Antibody (aa138-187) - LS-C146357 from LifeSpan Bioscience
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Anti-Endov antibody produced in rabbit - SAB2107134 from Sigma-Aldrich
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A730011L01Rik antibody - middle region (ARP55675_P050) - ARP55675_P050 from Aviva Systems Biology
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A730011L01Rik Antibody - GWB-MT947B from Genway Biotech
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Anti-ENDOV (aa 138-187) polyclonal antibody - DPABH-28376 from Creative Diagnostics
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A730011L01Rik-antibody-middle-region-AI13834 - AI13834 from Abgent, a WuXi AppTec company
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Endov antibody - orb326022 from Biorbyt
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Anti-A730011L01Rik Antibody A07888 - A07888 from Boster Bio
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A730011L01Rik antibody - middle region : Biotin (ARP55675_P050-Biotin) - ARP55675_P050-Biotin from Aviva Systems Biology
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A730011L01Rik antibody - middle region : FITC (ARP55675_P050-FITC) - ARP55675_P050-FITC from Aviva Systems Biology
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A730011L01Rik antibody - middle region : HRP (ARP55675_P050-HRP) - ARP55675_P050-HRP from Aviva Systems Biology
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Anti-ENDOV Antibody (aa138-187, Biotin) - LS-C460501 from LifeSpan Bioscience
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Anti-ENDOV Antibody (aa138-187, HRP) - LS-C460383 from LifeSpan Bioscience
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Anti-ENDOV Antibody (aa138-187, FITC) - LS-C460502 from LifeSpan Bioscience
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Endonuclease V antibody - orb183395 from Biorbyt
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