| Gene Symbol |
Endov
|
| Entrez Gene |
338371
|
| Alt Symbol |
A730011L01Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
endonuclease V
|
| Other Description |
novel endonuclease V protein|putative endonuclease FLJ39025 homolog
|
| Swissprots |
Q3TCQ4 Q8C9A2 B1ATE4 Q8C3Y1
|
| Accessions |
EDL34708 EDL34709 EDL34710 Q8C9A2 AK042626 BAC31310 AK084233 AK084548 BAC39216 AK170595 BAE41901 AK172181 BAE42869 AK179832 AK183732 AK209873 BC056486 AAH56486 BY266398 XM_006533589 XP_006533652 XM_011249087 XP_011247389 XR_388482 XR_879709 XR_879710 NM_001164636 NP_001158108 NM_177394 NP_796368
|
| Function |
Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm. Nucleus, nucleolus.
|
| Tissue Specificity |
Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain. {ECO:0000269|PubMed:12853604}.
|