| Gene Symbol | Endov |
|---|---|
| Entrez Gene | 338371 |
| Alt Symbol | A730011L01Rik |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | endonuclease V |
| Other Description | novel endonuclease V protein|putative endonuclease FLJ39025 homolog |
| Swissprots | Q3TCQ4 Q8C9A2 B1ATE4 Q8C3Y1 |
| Accessions | EDL34708 EDL34709 EDL34710 Q8C9A2 AK042626 BAC31310 AK084233 AK084548 BAC39216 AK170595 BAE41901 AK172181 BAE42869 AK179832 AK183732 AK209873 BC056486 AAH56486 BY266398 XM_006533589 XP_006533652 XM_011249087 XP_011247389 XR_388482 XR_879709 XR_879710 NM_001164636 NP_001158108 NM_177394 NP_796368 |
| Function | Endoribonuclease that specifically cleaves inosine- containing RNAs: cleaves RNA at the second phosphodiester bond 3' to inosine. Has strong preference for single-stranded RNAs (ssRNAs) toward double-stranded RNAs (dsRNAs). Cleaves mRNAs and tRNAs containing inosine. Also able to cleave structure-specific dsRNA substrates containing the specific sites 5'-IIUI-3' and 5'- UIUU-3'. Inosine is present in a number of RNAs following editing; the function of inosine-specific endoribonuclease is still unclear: it could either play a regulatory role in edited RNAs, or be involved in antiviral response by removing the hyperedited long viral dsRNA genome that has undergone A-to-I editing. Binds branched DNA structures (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. |
| Tissue Specificity | Highest levels detected in liver with high levels also found in heart, kidney and testis. Expressed at low levels in brain. {ECO:0000269|PubMed:12853604}. |
EndoV siRNA (m) - sc-140673 from Santa Cruz Biotechnology
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EndoV shRNA Plasmid (m) - sc-140673-SH from Santa Cruz Biotechnology
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EndoV shRNA (m) Lentiviral Particles - sc-140673-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU002481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN25978 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND25978 from Sigma-Aldrich
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ENDOV siRNA (Mouse) - CRN4722 from Cohesion Biosciences
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ENDOV - MBS8233181 from MyBioSource
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shRNA set against Mouse A730011L01Rik (NM_177394.3) - SHH228434 from Creative biogene
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Mouse ENDOV siRNA - orb294197 from Biorbyt
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ENDOV shRNA Plasmid (Mouse) - CHN4722 from Cohesion Biosciences
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