DNAJC2

Gene Symbol DNAJC2
Entrez Gene 27000
Alt Symbol MPHOSPH11, MPP11, ZRF1, ZUO1
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily C, member 2
Other Description M-phase phosphoprotein 11|dnaJ homolog subfamily C member 2|zuotin related factor 1|zuotin-related factor 1
Swissprots A4VCI0 Q9BVX1 Q99543
Accessions EAW83329 EAW83330 Q99543 AI621015 AK126382 AL832847 BC000859 AAH00859 BC012376 BC032854 BC046351 BC056682 BC062703 AAH62703 BC125057 AAI25058 BC139751 AAI39752 BC160045 AAI60045 DA272314 DA691752 X98260 CAA66913 XM_005250269 XP_005250326 XM_011516028 XP_011514330 XM_011516029 XP_011514331 XM_011516030 XP_011514332 NM_001129887 NP_001123359 NM_014377 NP_055192
Function Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
Subcellular Location Nucleus. Cytoplasm, cytosol.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11034098}.

Phospho-DNAJC2/MPP11 (Ser47) Antibody - 12397 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of 293T cells, untreated (-) or treated (+) with λ phosphatase and calf intestinal phosphatase (CIP), using Phospho-DNAJC2/MPP11 (Ser47) Antibody (upper) or α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

DNAJC2/MPP11 (D6B1E) Rabbit mAb - 12844 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6B1E
Western blot analysis of extracts from various cell lines using DNAJC2/MPP11 (D6B1E) Rabbit mAb.

Zuotin-1 (A-12) - sc-393426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Zuotin-1 (A-12): sc-393426. Western blot analysis of Zuotin-1 expression in HeLa (A), PC-3 (B), Hep G2 (C) and NIH/3T3 (D) whole cell lysates.

Zuotin-1 (I-17) - sc-79396 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zuotin-1 (I-17): sc-79396. Western blot analysis of Zuotin-1 expression in Jurkat (A) and K-562 (B) whole cell lysates.

Zuotin-1 (N-19) - sc-79397 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Zuotin-1 (N-19): sc-79397. Western blot analysis of Zuotin-1 expression in PC-3 whole cell lysate.

Anti-DNAJC2 antibody - ab103238 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-DNAJC2 antibody (ab103238) at 1/100 dilution + Mouse Neuro-2a cell line lysate at 35 µg

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, APC) - LS-C256193 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, AP) - LS-C256194 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, PE) - LS-C256196 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, Biotin) - LS-C256195 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, FITC) - LS-C256198 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255, Azide-free, HRP) - LS-C256197 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa226-255) - LS-C167474 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of DNAJC2 Antibody in mouse Neuro-2a cell line lysates (35 ug/lane). DNAJC2 (arrow) was detected using the purified antibody.

Anti-DNAJC2 / ZRF1 Antibody (aa571-621) - LS-C290379 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa500-550) - LS-C290375 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa233-263) - LS-C320896 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DNAJC2 / ZRF1 Antibody (aa417-466) - LS-C135643 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
DNAJC2 antibody LS-C135643 Western blot of Fetal Liver lysate.

Anti-DNAJC2 / ZRF1 Antibody - LS-C333472 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using DNAJC2 antibody.

DNAJC2 Antibody - NBP1-82627 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DNAJC2 Antibody [NBP1-82627] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

DNAJC2 Antibody - NBP2-12802 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: DNAJC2 Antibody [NBP2-12802] - Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-DNAJC2 antibody A303-722A used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. DNAJC2 was also immunoprecipitated by rabbit anti-DNAJC2 antibody NBP2-12802, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).

DNAJC2 Antibody - NBP2-12803 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: DNAJC2 Antibody [NBP2-12803] - Samples: Whole cell lysate from HeLa (15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded), 293T (T; 50 ug) and Jurkat (J; 50 ug) cells. Antibodies: Affinity purified rabbit anti-DNAJC2 antibody A303-722A used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 6 ug/mg lysate. DNAJC2 was also immunoprecipitated by rabbit anti-DNAJC2 antibody NBP2-12802, which recognizes an upstream epitope. Detection: Chemiluminescence with exposure times of 30 seconds (A) and 10 seconds (B).

ANTI-DNAJC2 (CENTER) antibody produced in rabbit - SAB1306930 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DNAJC2 (Center): <B>Cat. No. SAB1306930</B>: Western blot analysis of DNAJC2 Antibody (Center) in Mouse Neuro-2a cell line lysates (35 μg/lane).

Anti-DNAJC2 antibody produced in rabbit - HPA020454 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DNAJC2: <B>Cat. No. HPA020454</B>: Immunohistochemical staining of human rectum shows strong cytoplasmic positivity in glandular cells.

Monoclonal Anti-ZRF1 antibody produced in mouse - SAB1403192 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3F2
<B>Immunoblotting</B><BR/>Monoclonal Anti-ZRF1: <B>Cat. No. SAB1403192</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.2 kDa using immunogen protein lysate.

DNAJC2 antibody - C-terminal region (ARP59866_P050) - ARP59866_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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