| Gene Symbol |
DNAJC2
|
| Entrez Gene |
27000
|
| Alt Symbol |
MPHOSPH11, MPP11, ZRF1, ZUO1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DnaJ (Hsp40) homolog, subfamily C, member 2
|
| Other Description |
M-phase phosphoprotein 11|dnaJ homolog subfamily C member 2|zuotin related factor 1|zuotin-related factor 1
|
| Swissprots |
A4VCI0 Q9BVX1 Q99543
|
| Accessions |
EAW83329 EAW83330 Q99543 AI621015 AK126382 AL832847 BC000859 AAH00859 BC012376 BC032854 BC046351 BC056682 BC062703 AAH62703 BC125057 AAI25058 BC139751 AAI39752 BC160045 AAI60045 DA272314 DA691752 X98260 CAA66913 XM_005250269 XP_005250326 XM_011516028 XP_011514330 XM_011516029 XP_011514331 XM_011516030 XP_011514332 NM_001129887 NP_001123359 NM_014377 NP_055192
|
| Function |
Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:11034098}.
|