DNAJC2

Gene Symbol DNAJC2
Entrez Gene 27000
Alt Symbol MPHOSPH11, MPP11, ZRF1, ZUO1
Species Human
Gene Type protein-coding
Description DnaJ (Hsp40) homolog, subfamily C, member 2
Other Description M-phase phosphoprotein 11|dnaJ homolog subfamily C member 2|zuotin related factor 1|zuotin-related factor 1
Swissprots A4VCI0 Q9BVX1 Q99543
Accessions EAW83329 EAW83330 Q99543 AI621015 AK126382 AL832847 BC000859 AAH00859 BC012376 BC032854 BC046351 BC056682 BC062703 AAH62703 BC125057 AAI25058 BC139751 AAI39752 BC160045 AAI60045 DA272314 DA691752 X98260 CAA66913 XM_005250269 XP_005250326 XM_011516028 XP_011514330 XM_011516029 XP_011514331 XM_011516030 XP_011514332 NM_001129887 NP_001123359 NM_014377 NP_055192
Function Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb- repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'. {ECO:0000269|PubMed:15802566, ECO:0000269|PubMed:16002468, ECO:0000269|PubMed:21179169}.
Subcellular Location Nucleus. Cytoplasm, cytosol.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:11034098}.

Zuotin-1 CRISPR/Cas9 KO Plasmid (h) - sc-409891 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 HDR Plasmid (h) - sc-409891-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 Double Nickase Plasmid (h) - sc-409891-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 Double Nickase Plasmid (h2) - sc-409891-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 CRISPR Activation Plasmid (h) - sc-409891-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 CRISPR Activation Plasmid (h2) - sc-409891-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 Lentiviral Activation Particles (h) - sc-409891-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 Lentiviral Activation Particles (h2) - sc-409891-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Zuotin-1 siRNA (h) - sc-77019 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Zuotin-1 shRNA Plasmid (h) - sc-77019-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Zuotin-1 shRNA (h) Lentiviral Particles - sc-77019-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU114061 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7368 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7368 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

DNAJC2 siRNA (Human) - CRH8917 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DNAJC2 - MBS8223390 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human DNAJC2 (NM_014377.1) - SHH279545 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human ZRF1(NM_014377.1) - SHH224412 from Creative biogene

Category siRNA
Species Reactivities Human

Human DNAJC2 siRNA - orb269419 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

DNAJC2 shRNA Plasmid (Human) - CHH8917 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

DNAJC2 miRNA 3'UTR clone - MiUTR1H-11757 from Creative biogene

Species Reactivities Human

DNAJC2 miRNA 3'UTR clone - MiUTR3H-07739 from Creative biogene

Species Reactivities Human
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