TRMU

Gene Symbol	TRMU
Entrez Gene	55687
Alt Symbol	MTO2, MTU1, TRMT, TRMT1, TRNT1
Species	Human
Gene Type	protein-coding
Description	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
Other Description	MTO2 homolog\|mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase\|mitochondrial tRNA-specific 2-thiouridylase 1
Swissprots	Q9NWC1 Q6ICC3 Q66K31 A8K3U7 Q05C99 Q5W9C8 O75648
Accessions	AAL35970 EAW73422 EAW73423 EAW73424 EAW73425 EAW73426 O75648 AB178028 BAD66875 AK000212 AK001002 BAA91462 AK055295 AK093743 AK290712 BAF83401 AK295173 BAG58183 AK303020 BAG64147 AY062123 AAL38183 BC012076 BC027991 AAH27991 BC066593 BC080631 AAH80631 BM755897 BX952612 CN365141 CR456445 CAG30331 CU013043 CAK54474 CU013331 CAK54773 DN997542 DQ309998 ABC46690 DQ309999 ABC46691 DQ310000 ABC46692 XM_005261678 XP_005261735 XM_005261681 XP_005261738 XM_011530271 XP_011528573 XM_011530272 XP_011528574 XM_011530273 XP_011528575 XM_011530274 XP_011528576 XM_011530275 XP_011528577 NM_001282782 NP_001269711 NM_001282783 NP_001269712 NM_001282784 NP_001269713 NM_001282785 NP_001269714 NM_018006 NP_060476 NR_104240 NR_104241 NM_001008569 NM_001008571
Function	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. {ECO:0000269\|PubMed:15509579, ECO:0000269\|PubMed:15944150, ECO:0000269\|PubMed:16826519}.
Subcellular Location	Mitochondrion {ECO:0000269\|PubMed:15509579, ECO:0000269\|PubMed:15944150, ECO:0000269\|PubMed:16513084, ECO:0000269\|PubMed:16826519}.
Tissue Specificity	Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain. {ECO:0000269\|PubMed:16513084}.
Top Pathways	Sulfur relay system

TRMU (K-13) - sc-86923 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	100 µg/ml
Host	Rabbit
Clonality	Polyclonal

TRMU (H-95) - sc-368682 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Anti-TRMT1 antibody - ab138831 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMT1 antibody (ab138831) at 1/100 dilution + MDA-MB453 cell line lysates at 35 µg

Anti-TRMT1 antibody - ab168117 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-TRMT1 antibody (ab168117) at 1 µg/mlLane 1 : TRMT1 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG at 1/2500 dilution

Anti-TRMT1 antibody - ab56206 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154, Biotin) - LS-C272290 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154, FITC) - LS-C272291 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154, Azide-free, HRP) - LS-C272292 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154, PE) - LS-C272293 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154) - LS-C325978 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (clone 2B6) - LS-C174375 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2B6

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRMU (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRMU.

Anti-TRMU Antibody (clone 1C6) - LS-C174376 from LifeSpan Bioscience

Prices	$325.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	1C6

Anti-TRMU Antibody (aa60-109) - LS-C201553 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of Human Lung Tumor. TRMU antibody dilution 1.0 ug/ml.

Anti-TRMU Antibody (aa128-154) - LS-C157282 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

TRMU Antibody western blot of MDA-MB453 cell line lysates (35 ug/lane). The TRMU antibody detected the TRMU protein (arrow).

Anti-TRMU Antibody (C-Terminus) - LS-C81301 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-TRMU Antibody (clone 2A4) - LS-C174377 from LifeSpan Bioscience

Prices	$350.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	2A4

Anti-TRMU mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY TRMU.

Anti-TRMU Antibody (aa128-154, AP) - LS-C272288 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-TRMU Antibody (aa128-154, APC) - LS-C272289 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

TRNT1 Antibody - NBP1-57224 from Novus Biologicals

Prices	$299.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: TRNT1 Antibody [NBP1-57224] - Antibody Titration: 2.5ug/ml ELISA Titer: 1:62500 Positive Control: Human brain

TRNT1 Antibody - H00051095-B01 from Novus Biologicals

Host	Mouse
Clonality	Polyclonal

Western Blot: TRNT1 Antibody [H00051095-B01] - TRNT1 MaxPab polyclonal antibody (B01), Lot # 08065 WULz. Western Blot analysis of TRNT1 expression in rat brain.

TRMT1 Antibody - H00055687-B01 from Novus Biologicals

Prices	$349.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: TRMT1 Antibody [H00055687-B01] - analysis of TRMU expression in transfected 293T cell line by TRMU MaxPab polyclonal antibody (B01). Lane 1: TRMU transfected lysate (25.20 KDa). Lane 2: Non-transfected lysate.

TRMU Antibody - H00055687-B01P-50ug from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

ANTI-TRMU antibody produced in mouse - SAB1412686 from Sigma-Aldrich

Prices	$347.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-TRMU: <B>Cat. No. SAB1412686</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~24.4 kDa using TRMU transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Anti-TRMU antibody produced in rabbit - AV48819 from Sigma-Aldrich

Prices	$347.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Cell Type: HeLa (<B>Cat. No. AV48819</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HeLa

Anti-TRMU antibody produced in rabbit - HPA035273 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-TRMU: <B>Cat. No. HPA035273</B>: Immunohistochemical staining of human skeletal muscle shows strong cytoplasmic positivity.

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