Gene Symbol |
LIPH
|
Entrez Gene |
200879
|
Alt Symbol |
AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
lipase, member H
|
Other Description |
LPD lipase-related protein|lipase H|lipase member H|mPA-PLA1 alpha|membrane-associated phosphatidic acid-selective phospholipase A1-alpha|membrane-bound phosphatidic acid-selective phospholipase A1|phospholipase A1 member B
|
Swissprots |
Q8TEC7 A2IBA7 Q8WWY8
|
Accessions |
ABM67096 EAW78218 Q8WWY8 AK074229 BAB85023 AK122651 BAG53642 AK298380 BAG60616 AY036912 AAK63178 AY093498 AAM18803 BC064941 AAH64941 BI965988 EF186228 ABM67094 EF186229 ABM67095 HQ448078 ADQ32559 XM_006713529 XP_006713592 XM_011512530 XP_011510832 XM_011512531 XP_011510833 NM_139248 NP_640341
|
Function |
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}.
|
Subcellular Location |
Secreted. Membrane; Peripheral membrane protein.
|
Tissue Specificity |
Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region. {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12213196, ECO:0000269|PubMed:12719377, ECO:0000269|PubMed:17095700}.
|