Gene Symbol | LIPH |
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Entrez Gene | 200879 |
Alt Symbol | AH, ARWH2, HYPT7, LAH2, LPDLR, PLA1B, mPA-PLA1 |
Species | Human |
Gene Type | protein-coding |
Description | lipase, member H |
Other Description | LPD lipase-related protein|lipase H|lipase member H|mPA-PLA1 alpha|membrane-associated phosphatidic acid-selective phospholipase A1-alpha|membrane-bound phosphatidic acid-selective phospholipase A1|phospholipase A1 member B |
Swissprots | Q8TEC7 A2IBA7 Q8WWY8 |
Accessions | ABM67096 EAW78218 Q8WWY8 AK074229 BAB85023 AK122651 BAG53642 AK298380 BAG60616 AY036912 AAK63178 AY093498 AAM18803 BC064941 AAH64941 BI965988 EF186228 ABM67094 EF186229 ABM67095 HQ448078 ADQ32559 XM_006713529 XP_006713592 XM_011512530 XP_011510832 XM_011512531 XP_011510833 NM_139248 NP_640341 |
Function | Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}. |
Subcellular Location | Secreted. Membrane; Peripheral membrane protein. |
Tissue Specificity | Present in intestine (at protein level). Expressed in colon, prostate, kidney, pancreas, ovary, testis, intestine, lung and pancreas. Expressed at lower level in brain, spleen and heart. In hair, it is prominently expressed in hair follicles, including the stem cell-rich bulge region. {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12213196, ECO:0000269|PubMed:12719377, ECO:0000269|PubMed:17095700}. |
LIPH CRISPR/Cas9 KO Plasmid (h) - sc-408344 from Santa Cruz Biotechnology
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LIPH HDR Plasmid (h) - sc-408344-HDR from Santa Cruz Biotechnology
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LIPH Double Nickase Plasmid (h) - sc-408344-NIC from Santa Cruz Biotechnology
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LIPH Double Nickase Plasmid (h2) - sc-408344-NIC-2 from Santa Cruz Biotechnology
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LIPH CRISPR Activation Plasmid (h) - sc-408344-ACT from Santa Cruz Biotechnology
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LIPH CRISPR Activation Plasmid (h2) - sc-408344-ACT-2 from Santa Cruz Biotechnology
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LIPH Lentiviral Activation Particles (h) - sc-408344-LAC from Santa Cruz Biotechnology
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LIPH Lentiviral Activation Particles (h2) - sc-408344-LAC-2 from Santa Cruz Biotechnology
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LIPH siRNA (h) - sc-77880 from Santa Cruz Biotechnology
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LIPH shRNA Plasmid (h) - sc-77880-SH from Santa Cruz Biotechnology
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LIPH shRNA (h) Lentiviral Particles - sc-77880-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU135031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2534 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2534 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07669 from Sigma-Aldrich
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LIPH siRNA (Human) - CRJ6264 from Cohesion Biosciences
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shRNA set against Human LIPH (NM_139248.2) - SHH330691 from Creative biogene
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shRNA set against Human LIPH(NM_139248.2) - SHH151139 from Creative biogene
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Human LIPH siRNA - orb276765 from Biorbyt
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LIPH shRNA Plasmid (Human) - CHJ6264 from Cohesion Biosciences
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LIPH miRNA 3'UTR clone - MiUTR1H-05699 from Creative biogene
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