| Gene Symbol |
WASL
|
| Entrez Gene |
8976
|
| Alt Symbol |
N-WASP, NWASP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Wiskott-Aldrich syndrome-like
|
| Other Description |
neural Wiskott-Aldrich syndrome protein
|
| Swissprots |
A1JUI9 O00401 Q7Z746
|
| Accessions |
EAL24333 EAW83599 O00401 AK023554 AK131016 AK289795 BAF82484 AM295156 CAL26602 BC013776 BC028602 BC052955 AAH52955 CB990698 CF593336 CR749438 CAH18276 D88460 BAA20128 DB380642 NM_003941 NP_003932
|
| Function |
Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. {ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. {ECO:0000250}.
|
| Top Pathways |
Fc gamma R-mediated phagocytosis, Choline metabolism in cancer, Salmonella infection, Bacterial invasion of epithelial cells, Chemokine signaling pathway
|