Gene Symbol | WASL |
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Entrez Gene | 8976 |
Alt Symbol | N-WASP, NWASP |
Species | Human |
Gene Type | protein-coding |
Description | Wiskott-Aldrich syndrome-like |
Other Description | neural Wiskott-Aldrich syndrome protein |
Swissprots | A1JUI9 O00401 Q7Z746 |
Accessions | EAL24333 EAW83599 O00401 AK023554 AK131016 AK289795 BAF82484 AM295156 CAL26602 BC013776 BC028602 BC052955 AAH52955 CB990698 CF593336 CR749438 CAH18276 D88460 BAA20128 DB380642 NM_003941 NP_003932 |
Function | Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. {ECO:0000269|PubMed:19366662, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:22847007, ECO:0000269|PubMed:22921828}. |
Subcellular Location | Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated. {ECO:0000250}. |
Top Pathways | Fc gamma R-mediated phagocytosis, Choline metabolism in cancer, Salmonella infection, Bacterial invasion of epithelial cells, Chemokine signaling pathway |
Human N WASP (phospho ) peptide - ab42791 from Abcam
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Human N WASP (phospho Y256) peptide - ab42793 from Abcam
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Human N WASP (unmodified Y256) peptide - ab34474 from Abcam
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Human N WASP full length protein - ab132277 from Abcam
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Human N WASP peptide - ab42783 from Abcam
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Human N WASP peptide - ab32706 from Abcam
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Human N WASP protein fragment - ab152939 from Abcam
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WASL / N-WASP Antibody Blocking Peptide - LS-E23159 from LifeSpan Bioscience
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Recombinant Human N-WASP Protein - H00008976-P01 from Novus Biologicals
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Recombinant Human N-WASP Protein - H00008976-Q01 from Novus Biologicals
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WASL / N-WASP - H00008976-P01-10 from Acris Antibodies
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WASL / N-WASP - H00008976-P01-25 from Acris Antibodies
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WASL / N-WASP - H00008976-Q01 from Acris Antibodies
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WASL / N-WASP - H00008976-Q01-10 from Acris Antibodies
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WASL / N-WASP - H00008976-Q01-25 from Acris Antibodies
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WASL fusion protein - Ag5424 from Proteintech Group
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Recombinant Human WASL, His-tagged - WASL-3699H from Creative Biomart
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Recombinant Human WASL, GST-tagged - WASL-320H from Creative Biomart
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Recombinant Human WASL, MYC/DDK-tagged - WASL-321H from Creative Biomart
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Recombinant Human Neural Wiskott-Aldrich syndrome protein(WASL) - CSB-YP025973HU CSB-EP025973HU CSB-BP025973HU CSB-MP025973HU from Cusabio
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N-WASP - WX2005 from ECM Biosciences
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WASL / N-WASP - TP307967 from Acris Antibodies
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N-WASP (Ser-484/Ser-485) Peptide, Peptide - MBS474015 from MyBioSource
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N-WASP Peptide, Peptide - MBS474016 from MyBioSource
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phospho-N-WASP (Ser-484/Ser-485) Peptide, Peptide - MBS474044 from MyBioSource
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