| Gene Symbol | CLIC4 |
|---|---|
| Entrez Gene | 25932 |
| Alt Symbol | CLIC4L, H1, MTCLIC, huH1, p64H1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | chloride intracellular channel 4 |
| Other Description | chloride intracellular channel 4 like|chloride intracellular channel protein 4|intracellular chloride ion channel protein p64H1 |
| Swissprots | Q9UFW9 Q9Y696 Q9UQJ6 |
| Accessions | EAW95142 EAW95143 EAW95144 EAW95145 EAW95146 Q9Y696 AF097330 AAD38446 AF109196 AAD26136 AK001624 BAA91794 AK095959 BAG53175 AK301466 BAG62986 AK307142 AK315051 BAG37528 AL080061 AL117424 CAB55916 AL162008 AM393644 CAL38520 BC012444 AAH12444 BQ574968 BQ929781 CR533501 CAG38532 DA904028 DB091421 Z24740 Z24749 XM_011541202 XP_011539504 NM_013943 NP_039234 |
| Function | Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}. |
| Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. |
| Tissue Specificity | Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:17636002}. |