CLIC4

Gene Symbol CLIC4
Entrez Gene 25932
Alt Symbol CLIC4L, H1, MTCLIC, huH1, p64H1
Species Human
Gene Type protein-coding
Description chloride intracellular channel 4
Other Description chloride intracellular channel 4 like|chloride intracellular channel protein 4|intracellular chloride ion channel protein p64H1
Swissprots Q9UFW9 Q9Y696 Q9UQJ6
Accessions EAW95142 EAW95143 EAW95144 EAW95145 EAW95146 Q9Y696 AF097330 AAD38446 AF109196 AAD26136 AK001624 BAA91794 AK095959 BAG53175 AK301466 BAG62986 AK307142 AK315051 BAG37528 AL080061 AL117424 CAB55916 AL162008 AM393644 CAL38520 BC012444 AAH12444 BQ574968 BQ929781 CR533501 CAG38532 DA904028 DB091421 Z24740 Z24749 XM_011541202 XP_011539504 NM_013943 NP_039234
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.
Tissue Specificity Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:17636002}.

CLIC4 (D2A7D) Rabbit mAb - 12644 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2A7D
Western blot analysis of extracts from SW620 and A-204 cells using CLIC4 (D2A7D) Rabbit mAb.

CLIC (N-13) - sc-65034 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLIC (N-13): sc-65034. Western blot analysis of CLIC4 expression in non-transfected: sc-110760 (A) and human CLIC4 transfected: sc-113014 (B) 293 whole cell lysates.

CLIC (C-16) - sc-65033 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLIC (C-16): sc-65033. Western blot analysis of CLIC expression in non-transfected: sc-110760 (A) and human CLIC transfected: sc-113014 (B) 293 whole cell lysates.

CLIC (S-16) - sc-65035 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CLIC (S-16): sc-65035. Western blot analysis of CLIC expression in non-transfected: sc-110760 (A) and human CLIC transfected: sc-113014 (B) 293 whole cell lysates.

CLIC4 (45.42) - sc-135739 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CLIC4 (45.42): sc-135739. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.

CLIC4 (U-100) - sc-130723 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CLIC4 (U-100): sc-130723. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast carcinoma tissue showing cytoplasmic localization.

CLIC4/5/6 (H-70) - sc-135031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CLIC4/5/6 (H-70): sc-135031. Western blot analysis of CLIC4 expression in non-transfected 293T: sc-117752 (A), human CLIC4 transfected 293T: sc-113014 (B), SK-N-MC (C), JAR (D), Raji (E) and U-251-MG (F) whole cell lysates.

Anti-CLIC4 antibody - ab76593 from Abcam

Prices $378.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CLIC4 antibody (ab76593) at 1/50 dilutionLane 1 : Non transfected 293 cell lysates Lane 2 : CLIC4 transfected 293 cell lysates Lysates/proteins at 2 µg per lane.

Anti-CLIC4 antibody - ab136056 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CLIC4 antibody (ab136056) at 1/500 dilution + HeLa cell lysates at 30 µg

Anti-CLIC4 antibody - ab130390 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-CLIC4 antibody [EPR14253] - ab183043 from Abcam

Prices $387.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14253
All lanes : Anti-CLIC4 antibody [EPR14253] (ab183043) at 1/10000 dilutionLane 1 : HeLa lysateLane 2 : 293 lysateLane 3 : Raji lysateLane 4 : HepG2 lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilutiondeveloped using the ECL technique

Anti-CLIC4 Antibody (N-Terminus) IHC-plus™ - LS-B2383 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CLIC4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2383 concentration 5 ug/ml.

Anti-CLIC4 Antibody - LS-C121164 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa20-69) - LS-C291821 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253) - LS-C293309 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253, Biotin) - LS-C299642 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253, Biotin) - LS-C299644 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253, Biotin) - LS-C299646 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253, FITC) - LS-C301972 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253, FITC) - LS-C301973 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (aa104-253) - LS-C293308 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CLIC4.

Anti-CLIC4 Antibody (aa104-253) - LS-C293310 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant CLIC4.

Anti-CLIC4 Antibody (aa104-253, FITC) - LS-C301974 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CLIC4 Antibody (clone 17CT9.2.8) - LS-C96444 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 17CT9.2.8
Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CLIC4 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-CLIC4 Antibody - LS-C100187 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with CLIC4 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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