CLIC4

Gene Symbol	CLIC4
Entrez Gene	25932
Alt Symbol	CLIC4L, H1, MTCLIC, huH1, p64H1
Species	Human
Gene Type	protein-coding
Description	chloride intracellular channel 4
Other Description	chloride intracellular channel 4 like|chloride intracellular channel protein 4|intracellular chloride ion channel protein p64H1
Swissprots	Q9UFW9 Q9Y696 Q9UQJ6
Accessions	EAW95142 EAW95143 EAW95144 EAW95145 EAW95146 Q9Y696 AF097330 AAD38446 AF109196 AAD26136 AK001624 BAA91794 AK095959 BAG53175 AK301466 BAG62986 AK307142 AK315051 BAG37528 AL080061 AL117424 CAB55916 AL162008 AM393644 CAL38520 BC012444 AAH12444 BQ574968 BQ929781 CR533501 CAG38532 DA904028 DB091421 Z24740 Z24749 XM_011541202 XP_011539504 NM_013943 NP_039234
Function	Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.
Tissue Specificity	Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:17636002}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CLIC4 full length protein - ab104744 from Abcam Category Protein Source E. coli Species Human

Human CLIC4 full length protein - ab125646 from Abcam Category Protein Source E. coli Species Human

CLIC4 Antibody Blocking Peptide - LS-E26316 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLIC4 Antibody Blocking Peptide - LS-E9059 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLIC4 Antibody Blocking Peptide - LS-E12527 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CLIC4 Partial Recombinant Protein - H00025932-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CLIC4 Protein - NBP1-51032 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 100 µg, 500 µg Source E. coli Species Human

CLIC4 Recombinant Protein - P3572 from Novus Biologicals Category Protein Prices $669.00 Sizes 100 µg Species Human

CLIC4-Antibody-Blocking-Peptide - BP7564a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CLIC4 blocking peptide - GTX89013-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat

CLIC4 Protein (OPPA00102) - OPPA00102 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human CLIC4 protein - orb168128 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

Human CLIC4 protein - orb49297 from Biorbyt Category Protein Prices $408.00, $595.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

CLIC4 Blocking Peptide - 33R-5440 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CLIC4 protein (His tag) - 80R-1719 from Fitzgerald Category Protein Prices $340.00 Sizes 100 µg Source E.coli

Human CLIC4 Protein - abx065871 from Abbexa Category Protein Source E.coli Species Human

CLIC4 Peptide - AC21-1151-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CLIC4 (1-253, His-tag) - AR09901PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 500 µg Source E. coli Species Human

CLIC4 (1-253, His-tag) - AR09901PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 100 µg Source E. coli Species Human

CLIC4 - H00025932-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CLIC4 - H00025932-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CLIC4 - P3572 from Acris Antibodies Category Protein Prices $580.00 Sizes 100 µg Species Human

Chloride Intracellular Channel 4, Human Recombinant - 228-12927-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Chloride Intracellular Channel 4 - 228-12927-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Chloride Intracellular Channel 4 - 228-12927-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

Search more