CLIC4

Gene Symbol CLIC4
Entrez Gene 25932
Alt Symbol CLIC4L, H1, MTCLIC, huH1, p64H1
Species Human
Gene Type protein-coding
Description chloride intracellular channel 4
Other Description chloride intracellular channel 4 like|chloride intracellular channel protein 4|intracellular chloride ion channel protein p64H1
Swissprots Q9UFW9 Q9Y696 Q9UQJ6
Accessions EAW95142 EAW95143 EAW95144 EAW95145 EAW95146 Q9Y696 AF097330 AAD38446 AF109196 AAD26136 AK001624 BAA91794 AK095959 BAG53175 AK301466 BAG62986 AK307142 AK315051 BAG37528 AL080061 AL117424 CAB55916 AL162008 AM393644 CAL38520 BC012444 AAH12444 BQ574968 BQ929781 CR533501 CAG38532 DA904028 DB091421 Z24740 Z24749 XM_011541202 XP_011539504 NM_013943 NP_039234
Function Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). {ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789}.
Subcellular Location Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus matrix. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.
Tissue Specificity Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle. {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:17200346, ECO:0000269|PubMed:17636002}.

CLIC4 CRISPR/Cas9 KO Plasmid (h) - sc-403188 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 HDR Plasmid (h) - sc-403188-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 Double Nickase Plasmid (h) - sc-403188-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 Double Nickase Plasmid (h2) - sc-403188-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 CRISPR Activation Plasmid (h) - sc-403188-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 CRISPR Activation Plasmid (h2) - sc-403188-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 Lentiviral Activation Particles (h) - sc-403188-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 Lentiviral Activation Particles (h2) - sc-403188-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CLIC4 siRNA (h) - sc-105213 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLIC4 shRNA Plasmid (h) - sc-105213-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLIC4 shRNA (h) Lentiviral Particles - sc-105213-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CLIC4 RNAi - H00025932-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU104701 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6231 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6231 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CLIC4 siRNA (Human) - CRH8598 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

CLIC4 - MBS8206791 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human CLIC4 (NM_013943.2) - SHH265309 from Creative biogene

Category siRNA
Species Reactivities Human

CLIC4 shRNA Plasmid (Human) - CHH8598 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

CLIC4 miRNA 3'UTR clone - MiUTR4H-TG02178 from Creative biogene

Species Reactivities Human
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