| Gene Symbol |
CHMP1A
|
| Entrez Gene |
5119
|
| Alt Symbol |
CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
charged multivesicular body protein 1A
|
| Other Description |
charged multivesicular body protein 1/chromatin modifying protein 1|charged multivesicular body protein 1a|chromatin modifying protein 1A|procollagen (type III) N-endopeptidase|protease, metallo, 1, 33kD|vacuolar protein sorting-associated protein 46-1
|
| Swissprots |
Q14468 Q15779 Q96G31 A2RU09 Q9HD42
|
| Accessions |
EAW66715 EAW66716 EAW66717 Q9HD42 AF281063 AAG01448 AI356110 AI362697 AK302055 BAG63445 BC007527 BC010000 AAH10000 BC132711 AAI32712 BC132713 AAI32714 BG480548 BI826757 BT006841 AAP35487 BX363674 CF131483 D38554 BAA07557 HQ258103 ADR82857 HY008690 HY089525 U58048 AAC50775 XM_011523097 XP_011521399 XM_011523098 XP_011521400 XM_011523099 XP_011521401 NM_001083314 NP_001076783 NM_002768 NP_002759 NR_046418
|
| Function |
Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
|
| Subcellular Location |
Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
|
| Tissue Specificity |
Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. {ECO:0000269|PubMed:8863740}.
|
