CHMP1A

Gene Symbol	CHMP1A
Entrez Gene	5119
Alt Symbol	CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 1A
Other Description	charged multivesicular body protein 1/chromatin modifying protein 1|charged multivesicular body protein 1a|chromatin modifying protein 1A|procollagen (type III) N-endopeptidase|protease, metallo, 1, 33kD|vacuolar protein sorting-associated protein 46-1
Swissprots	Q14468 Q15779 Q96G31 A2RU09 Q9HD42
Accessions	EAW66715 EAW66716 EAW66717 Q9HD42 AF281063 AAG01448 AI356110 AI362697 AK302055 BAG63445 BC007527 BC010000 AAH10000 BC132711 AAI32712 BC132713 AAI32714 BG480548 BI826757 BT006841 AAP35487 BX363674 CF131483 D38554 BAA07557 HQ258103 ADR82857 HY008690 HY089525 U58048 AAC50775 XM_011523097 XP_011521399 XM_011523098 XP_011521400 XM_011523099 XP_011521401 NM_001083314 NP_001076783 NM_002768 NP_002759 NR_046418
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Tissue Specificity	Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. {ECO:0000269|PubMed:8863740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human CHMP1a full length protein - ab139206 from Abcam Category Protein Source E. coli Species Human

CHMP1A Antibody Blocking Peptide - LS-E4541 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP1a Recombinant Protein - H00005119-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CHMP1a Recombinant Protein - H00005119-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Species Human

Recombinant Human CHMP1a Protein - NBP2-22770 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E.coli Species Human

CHMP1A-Antibody-N-term-Blocking-Peptide - BP16882a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human CHMP1A protein - orb168111 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 2 μg, 10 μg, 100 μg Species Human

CHMP1A protein (His tag) - 30R-2905 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

CHMP1A (1-196, His-tag) - AR50665PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

CHMP1A (1-196, His-tag) - AR50665PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

CHMP1A - H00005119-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CHMP1A - H00005119-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CHMP1A - H00005119-P02 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

CHMP1A, 1-196aa, Human, His tag, E.coli - 01-P1841 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

CHMP1A fusion protein - Ag8389 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

CHMP1A fusion protein - Ag8376 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Human CHMP1A Recombinant Protein - GWB-PPAT03 from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 20 μg, 100 μg Source E.coli Species Human

Recombinant Human CHMP1A, His-tagged - CHMP1A-7059H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CHMP1A, GST-tagged - CHMP1A-11182H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Charged multivesicular body protein 1a(CHMP1A) - CSB-YP881032HU CSB-EP881032HU CSB-BP881032HU CSB-MP881032HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

CHMP1A, 1-196aa, Human, His tag, E.coli - ATGP1841 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

CHMP1A (transcript variant 2) - TP314991 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CHMP1A Peptide, Human - M34GP03100H from Creative Peptides Category Peptide Source Synthetic. Species Human

CHMP1A - PAT-81842-1 from Nordic BioSite Category Protein Species Human

CHMP1A - PAT-81842-2 from Nordic BioSite Category Protein Species Human

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