CHMP1A

Gene Symbol	CHMP1A
Entrez Gene	5119
Alt Symbol	CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 1A
Other Description	charged multivesicular body protein 1/chromatin modifying protein 1|charged multivesicular body protein 1a|chromatin modifying protein 1A|procollagen (type III) N-endopeptidase|protease, metallo, 1, 33kD|vacuolar protein sorting-associated protein 46-1
Swissprots	Q14468 Q15779 Q96G31 A2RU09 Q9HD42
Accessions	EAW66715 EAW66716 EAW66717 Q9HD42 AF281063 AAG01448 AI356110 AI362697 AK302055 BAG63445 BC007527 BC010000 AAH10000 BC132711 AAI32712 BC132713 AAI32714 BG480548 BI826757 BT006841 AAP35487 BX363674 CF131483 D38554 BAA07557 HQ258103 ADR82857 HY008690 HY089525 U58048 AAC50775 XM_011523097 XP_011521399 XM_011523098 XP_011521400 XM_011523099 XP_011521401 NM_001083314 NP_001076783 NM_002768 NP_002759 NR_046418
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Tissue Specificity	Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. {ECO:0000269|PubMed:8863740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP1A (B-5) - sc-271617 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHMP1A (FL-196) - sc-67205 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CHMP1A (K-17) - sc-49904 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CHMP1a antibody - ab198170 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1a antibody - ab104100 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP1a antibody - ab104103 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP1a antibody [EPR11938(B)] - ab167412 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11938(B)

Anti-CHMP1a antibody [EPR11939] - ab178686 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR11939

Anti-CHMP1A Antibody (aa33-61, AP) - LS-C254749 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61, FITC) - LS-C254753 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61, APC) - LS-C254751 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61, Biotin) - LS-C254752 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61, PE) - LS-C254755 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61, Azide-free, HRP) - LS-C254754 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody - LS-C306945 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61) - LS-C320356 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody - LS-C309908 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-CHMP1A Antibody (aa33-61) - LS-C168737 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

CHMP1a Antibody - NBP1-84483 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP1a Antibody - H00005119-B02P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP1a Antibody - H00005119-B02 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

CHMP1a Antibody - H00005119-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

CHMP1a Antibody - H00005119-D01P from Novus Biologicals Prices $399.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

CHMP1a Antibody - H00005119-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

CHMP1A Polyclonal Antibody - bs-4207R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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