CHMP1A

Gene Symbol	CHMP1A
Entrez Gene	5119
Alt Symbol	CHMP1, PCH8, PCOLN3, PRSM1, VPS46-1, VPS46A
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 1A
Other Description	charged multivesicular body protein 1/chromatin modifying protein 1|charged multivesicular body protein 1a|chromatin modifying protein 1A|procollagen (type III) N-endopeptidase|protease, metallo, 1, 33kD|vacuolar protein sorting-associated protein 46-1
Swissprots	Q14468 Q15779 Q96G31 A2RU09 Q9HD42
Accessions	EAW66715 EAW66716 EAW66717 Q9HD42 AF281063 AAG01448 AI356110 AI362697 AK302055 BAG63445 BC007527 BC010000 AAH10000 BC132711 AAI32712 BC132713 AAI32714 BG480548 BI826757 BT006841 AAP35487 BX363674 CF131483 D38554 BAA07557 HQ258103 ADR82857 HY008690 HY089525 U58048 AAC50775 XM_011523097 XP_011521399 XM_011523098 XP_011521400 XM_011523099 XP_011521401 NM_001083314 NP_001076783 NM_002768 NP_002759 NR_046418
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm. Endosome membrane; Peripheral membrane protein. Nucleus matrix. Note=The cytoplasmic form is partially membrane-associated and localizes to early endosomes. The nuclear form remains associated with the chromosome scaffold during mitosis. On overexpression, it localizes to nuclear bodies characterized by nuclease-resistant condensed chromatin.
Tissue Specificity	Expressed in placenta, cultured skin fibroblasts and in osteoblast cell line MG-63. {ECO:0000269|PubMed:8863740}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP1A CRISPR/Cas9 KO Plasmid (h) - sc-406556 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A HDR Plasmid (h) - sc-406556-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A Double Nickase Plasmid (h) - sc-406556-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A Double Nickase Plasmid (h2) - sc-406556-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A CRISPR Activation Plasmid (h) - sc-406556-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A CRISPR Activation Plasmid (h2) - sc-406556-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A Lentiviral Activation Particles (h) - sc-406556-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A Lentiviral Activation Particles (h2) - sc-406556-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A siRNA (h) - sc-60367 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHMP1A shRNA Plasmid (h) - sc-60367-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHMP1A shRNA (h) Lentiviral Particles - sc-60367-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CHMP1a RNAi - H00005119-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU143441 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN6068 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6068 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR10077 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr10077

CHMP1A siRNA (Human) - CRH3404 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHMP1A - MBS8237609 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHMP1A CRISPR/Cas9 KO Plasmid (h2) - sc-406556-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CHMP1A HDR Plasmid (h2) - sc-406556-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human CHMP1A (NM_002768.3) - SHH263165 from Creative biogene Category siRNA Species Reactivities Human

Human CHMP1A siRNA - orb263906 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CHMP1A shRNA Plasmid (Human) - CHH3404 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

CHMP1A miRNA 3'UTR clone - MiUTR3H-01559 from Creative biogene Species Reactivities Human

CHMP1A miRNA 3'UTR clone - MiUTR3H-01560 from Creative biogene Species Reactivities Human

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