| Gene Symbol | KAZN |
|---|---|
| Entrez Gene | 23254 |
| Alt Symbol | KAZ |
| Species | Human |
| Gene Type | protein-coding |
| Description | kazrin, periplakin interacting protein |
| Other Description | kazrin |
| Swissprots | Q9UPX4 Q674X6 Q674X7 B1AK78 Q674X4 Q8IYN7 B0QYQ0 Q5TGF1 Q9UIL2 Q6ZUD1 Q8N409 |
| Accessions | EAW51704 Q674X7 AB015329 BAA88115 AF052120 AK057155 AK125388 AK293806 BAG57213 AY505119 AAS86434 AY505120 AAS86435 AY505121 AAS86436 AY505122 AAS86437 BC035501 AAH35501 BC101637 AAI01638 BC113621 AAI13622 BC143641 AAI43642 BI916330 DA317442 DN831635 DR003677 XM_005245795 XP_005245852 XM_011541074 XP_011539376 XM_011541075 XP_011539377 XM_011541076 XP_011539378 XM_011541077 XP_011539379 XM_011541078 XP_011539380 XM_011541079 XP_011539381 XM_011541080 XP_011539382 XM_011541081 XP_011539383 XM_011541082 XP_011539384 NM_001017999 NP_001017999 NM_001018000 NP_001018000 NM_001018001 NP_001018001 NM_015209 NP_056024 NM_201628 NP_963922 |
| Function | Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. {ECO:0000269|PubMed:15337775}. |
| Subcellular Location | Isoform 3: Cytoplasm. Cell junction, desmosome. Nucleus. Note=Observed at the apical plasma membrane of keratinocytes. Partially colocalizes with PPL and DP at desmosomes, and with PP at the interdesmosomal plasma membrane. Colocalizes with cortical actin-based membrane structures. |
| Tissue Specificity | Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicular epidermis (at protein level). {ECO:0000269|PubMed:15337775}. |
Kazrin CRISPR/Cas9 KO Plasmid (h) - sc-408206 from Santa Cruz Biotechnology
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Kazrin HDR Plasmid (h) - sc-408206-HDR from Santa Cruz Biotechnology
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Kazrin Double Nickase Plasmid (h) - sc-408206-NIC from Santa Cruz Biotechnology
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Kazrin Double Nickase Plasmid (h2) - sc-408206-NIC-2 from Santa Cruz Biotechnology
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Kazrin CRISPR Activation Plasmid (h) - sc-408206-ACT from Santa Cruz Biotechnology
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Kazrin CRISPR Activation Plasmid (h2) - sc-408206-ACT-2 from Santa Cruz Biotechnology
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Kazrin Lentiviral Activation Particles (h) - sc-408206-LAC from Santa Cruz Biotechnology
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Kazrin Lentiviral Activation Particles (h2) - sc-408206-LAC-2 from Santa Cruz Biotechnology
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Kazrin siRNA (h) - sc-78617 from Santa Cruz Biotechnology
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Kazrin shRNA Plasmid (h) - sc-78617-SH from Santa Cruz Biotechnology
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Kazrin shRNA (h) Lentiviral Particles - sc-78617-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10902 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10902 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14092 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02177 from Sigma-Aldrich
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KAZN siRNA (Human) - CRH8127 from Cohesion Biosciences
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KAZN, siRNA - MBS8215559 from MyBioSource
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shRNA set against Human KAZN (NM_001018000.3) - SHH322523 from Creative biogene
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shRNA set against Human KIAA1026(NM_015209.2) - SHL195182 from Creative biogene
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shRNA set against Human KIAA1026(NM_001017999.2) - SHL195336 from Creative biogene
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shRNA set against Human KIAA1026(NM_001018000.3) - SHL195408 from Creative biogene
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KAZN shRNA Plasmid (Human) - CHH8127 from Cohesion Biosciences
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KAZN miRNA 3'UTR clone - MiUTR1H-03758 from Creative biogene
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KAZN miRNA 3'UTR clone - MiUTR1H-05241 from Creative biogene
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KAZN miRNA 3'UTR clone - MiUTR1H-05242 from Creative biogene
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