| Gene Symbol |
RAB12
|
| Entrez Gene |
201475
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB12, member RAS oncogene family
|
| Other Description |
putative Ras-related protein Rab-12|ras-related protein Rab-12
|
| Swissprots |
Q4KMQ3 A6NEF5 Q6IQ22
|
| Accessions |
EAX01616 Q6IQ22 AK127824 BC050338 BC071600 AAH71600 BC098407 AAH98407 XM_006722300 XP_006722363 NM_001025300 NP_001020471
|
| Function |
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}.
|
![Western Blot: RAB12 Overexpression Lysate (Adult Normal) [NBP2-08632] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RAB12.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5452_RAB12%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08632-img0001.jpg)