Gene Symbol | RAB12 |
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Entrez Gene | 201475 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | RAB12, member RAS oncogene family |
Other Description | putative Ras-related protein Rab-12|ras-related protein Rab-12 |
Swissprots | Q4KMQ3 A6NEF5 Q6IQ22 |
Accessions | EAX01616 Q6IQ22 AK127824 BC050338 BC071600 AAH71600 BC098407 AAH98407 XM_006722300 XP_006722363 NM_001025300 NP_001020471 |
Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250}. |
Subcellular Location | Recycling endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. |
Rab 12 CRISPR/Cas9 KO Plasmid (h) - sc-415015 from Santa Cruz Biotechnology
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Rab 12 HDR Plasmid (h) - sc-415015-HDR from Santa Cruz Biotechnology
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Rab 12 Double Nickase Plasmid (h) - sc-415015-NIC from Santa Cruz Biotechnology
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Rab 12 Double Nickase Plasmid (h2) - sc-415015-NIC-2 from Santa Cruz Biotechnology
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Rab 12 CRISPR Activation Plasmid (h) - sc-415015-ACT from Santa Cruz Biotechnology
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Rab 12 CRISPR Activation Plasmid (h2) - sc-415015-ACT-2 from Santa Cruz Biotechnology
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Rab 12 Lentiviral Activation Particles (h) - sc-415015-LAC from Santa Cruz Biotechnology
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Rab 12 Lentiviral Activation Particles (h2) - sc-415015-LAC-2 from Santa Cruz Biotechnology
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Rab 12 siRNA (h) - sc-76311 from Santa Cruz Biotechnology
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Rab 12 shRNA Plasmid (h) - sc-76311-SH from Santa Cruz Biotechnology
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Rab 12 shRNA (h) Lentiviral Particles - sc-76311-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN17809 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17809 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08102 from Sigma-Aldrich
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RAB12 siRNA (Human) - CRJ6293 from Cohesion Biosciences
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RAB12 - MBS8213201 from MyBioSource
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shRNA set against Human RAB12 (NM_001025300.2) - SHH387900 from Creative biogene
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shRNA set against Human RAB12(NM_001025300.2) - SHR157650 from Creative biogene
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RAB12 shRNA Plasmid (Human) - CHJ6293 from Cohesion Biosciences
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RAB12 miRNA 3'UTR clone - MiUTR1H-08542 from Creative biogene
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