SORT1

Gene Symbol	SORT1
Entrez Gene	6272
Alt Symbol	Gp95, LDLCQ6, NT3
Species	Human
Gene Type	protein-coding
Description	sortilin 1
Other Description	100 kDa NT receptor|NTR3|glycoprotein 95|neurotensin receptor 3|sortilin
Swissprots	Q99523 Q8IZ49 C0JYZ0 B4DWI3
Accessions	ACN81319 CCF77015 EAW56380 Q99523 AA782785 AI623426 AI695671 AK000757 AK023648 AK129918 AK130545 AK293118 BAF85807 AK301548 BAG63045 AK310147 AL117561 AU132384 BC023542 AAH23542 BC041982 BC053575 BF591118 BQ001031 BQ774407 BX955818 CB267773 DA023768 DB045034 DQ896793 ABM87792 XM_005271100 XP_005271157 XM_005271101 XP_005271158 XM_005271102 XP_005271159 XM_006710812 XP_006710875 NM_001205228 NP_001192157 NM_002959 NP_002950
Function	Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|P
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Tissue Specificity	Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:9013611}.
Top Pathways	Neurotrophin signaling pathway, Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SORT1 / Sortilin ELISA Kit (Sandwich ELISA) - LS-F6828 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Sortilin (SORT1), Human, ELISA Kit - CSB-EL022412HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 11.72 pg/ml Range 46.88 pg/ml-3000 pg/ml

Human Sortilin (Soluble) ELISA KIT - DEIA7080 from Creative Diagnostics Category ELISA Kit Sensitivity 100 pg/mL Range 1.56-100 ng/mL

Human Sortilin (Soluble) ELISA Kit - DEIA7081 from Creative Diagnostics Category ELISA Kit Sensitivity 100 pg/mL Range 0.39 - 400 ng/mL

SORT1, ELISA Kit - MBS2516354 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.094ng/mL Range 0.156-10ng/mL

sortilin 1, ELISA Kit - MBS940316 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 11.72 pg/ml Range 46.88 pg/ml-3000 pg/ml

Sortilin 1, ELISA Kit - MBS090946 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin 1, ELISA Kit - MBS067667 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin 1, ELISA Kit - MBS061365 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1ng/ml. Range 0.25ng/ml-8ng/ml.

Sortilin 1, ELISA Kit - MBS070360 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin 1, ELISA Kit - MBS079072 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin 1, ELISA Kit - MBS097013 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sortilin 1 (SORT1), ELISA Kit - MBS2020972 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.064ng/mL. Range 0.156-10ng/mL

Sortilin 1 (SORT1), ELISA Kit - MBS2024890 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of SORT1 is typically less than 0.066ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration. Range 0.156-10ng/mL. The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.312ng/mL, 0.156ng/mL.

ELISA Kit for Sortilin 1 (SORT1) - SEC895Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.064ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Sortilin 1 (SORT1) - SEC895Mu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Sortilin(SORT1) ELISA kit - CSB-EL022412HU from Cusabio Category ELISA Kit Sensitivity 11.72 pg/ml Range 46.88 pg/ml-3000 pg/ml

Sortilin 1, ELISA Kit - MBS084065 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human Sortilin 1 (SORT1) ELISA Kit - EKU07417 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.064 ng/mL Range 0.156-10 ng/mL

Human SORT1(Sortilin 1) ELISA Kit - E-EL-H5414 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mLng/mL Range 0.16~10 ng/mL

Human Sortilin 1 ELISA Kit - abx153138 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

Custom Human Sortilin ELISA - ELH-SORT1 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human SORT1 / Sortilin ELISA Kit (Sandwich ELISA) - LS-F21281 from LifeSpan Bioscience Category ELISA Kit Prices $590.00 Sizes 1 plate Sensitivity 0.16 ng/ml Range 0.156-10 ng/ml

Sortilin 1 (SORT1), Human, ELISA Kit - DL-SORT1-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse SORT1 / Sortilin ELISA Kit (Sandwich ELISA) - LS-F25393 from LifeSpan Bioscience Category ELISA Kit Prices $800.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

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