SORT1

Gene Symbol SORT1
Entrez Gene 6272
Alt Symbol Gp95, LDLCQ6, NT3
Species Human
Gene Type protein-coding
Description sortilin 1
Other Description 100 kDa NT receptor|NTR3|glycoprotein 95|neurotensin receptor 3|sortilin
Swissprots Q99523 Q8IZ49 C0JYZ0 B4DWI3
Accessions ACN81319 CCF77015 EAW56380 Q99523 AA782785 AI623426 AI695671 AK000757 AK023648 AK129918 AK130545 AK293118 BAF85807 AK301548 BAG63045 AK310147 AL117561 AU132384 BC023542 AAH23542 BC041982 BC053575 BF591118 BQ001031 BQ774407 BX955818 CB267773 DA023768 DB045034 DQ896793 ABM87792 XM_005271100 XP_005271157 XM_005271101 XP_005271158 XM_005271102 XP_005271159 XM_006710812 XP_006710875 NM_001205228 NP_001192157 NM_002959 NP_002950
Function Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|P
Subcellular Location Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Tissue Specificity Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:9013611}.
Top Pathways Neurotrophin signaling pathway, Lysosome

NTR3 (C-19) - sc-31699 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTR3 (C-19): sc-31699. Western blot analysis of NTR3 expression in SW480 (A), SH-SY5Y (B) and SK-N-SH (C) whole cell lysates.

NTR3 (E-9) - sc-376576 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NTR3 (E-9): sc-376576. Western blot analysis of NTR3 expression in MIA PaCa-2 whole cell lysate.

NTR3 (C-20) - sc-25055 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTR3 (C-20): sc-25055. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

NTR3 (F-15) - sc-31698 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTR3 (F-15): sc-31698. Western blot analysis of NTR3 expression in SW480 whole cell lysate.

NTR3 (G-11) - sc-376561 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NTR3 (G-11): sc-376561. Western blot analysis of NTR3 expression in MIA PaCa-2 (A) and SW480 (B) whole cell lysates.

NTR3 (H-300) - sc-30217 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NTR3 (H-300): sc-30217. Western blot analysis of NTR3 expression in MIA PaCa-2 whole cell lysate.

NTR3 (N-17) - sc-25053 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NTR3 (N-17): sc-25053. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Anti-Sortilin antibody - ab16640 from Abcam

Prices $403.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescent staining for Sortilin in rat cortical neurons using Rabbit polyclonal to Sortilin (ab16640). The staining is cytoplasmic and punctate of many cells such as cortical neurons. The image was taken with a X20 objective.Protocol details: Rats were intracardially perfused with 4% paraformaldehyde. Whole brain tissue was post-fixed overnight in the same fixative, cryoprotected in 20% sucrose and frozen in OCT and then cut on cryostat (30µm coronal sections). IHC was perfored in free floating with fixed tissues (rat brain sections). Primary antibody was incubated overnight at 1/3000 at room temperature. Secondary antibody Alexa fluor 488 1/1000 for 2 hours at room temperature.

Anti-Sortilin antibody - ab36959 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab36959 staining Sortilin in Human primary monocytes and macrophages by Flow Cytometry. The sample was incubated with the primary antibody (5µg/ml in DPBS + 2% FBS and 0.1% sodium azide) for 1 hour at 4°C. An Alexa Flour® 647 -conjugated goat anti-rabbit IgG polyclonal (5µg/ml) was used as the secondary antibody.Gating Strategy: Either monocytes or macrophages.Red - sortilin, blue - control IgG.See Abreview

Anti-Sortilin antibody - ab57672 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57672 Sortilin antibody at 1ug/ml.

Anti-Sortilin antibody [EPR15010] - ab188586 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR15010
All lanes : Anti-Sortilin antibody [EPR15010] (ab188586) at 1/2000 dilutionLane 1 : SW480 cell lysateLane 2 : HeLa cell lysateLane 3 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-SORT1 / Sortilin Antibody (N-Terminus) - LS-C94842 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody (Cytoplasmic Domain) - LS-C94912 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody - LS-C333057 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of Mouse brain, using SORT1 antibody.

Anti-SORT1 / Sortilin Antibody (clone 1B3) - LS-C198140 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B3
SORT1 monoclonal antibody (M01), clone 1B3. Western Blot analysis of SORT1 expression in human spleen.

Anti-SORT1 / Sortilin Antibody (N-Terminus) - LS-C94818 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody (N-Terminus) - LS-C94806 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody (Extracellular Domain) - LS-C37627 from LifeSpan Bioscience

Prices $545.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody (N-Terminus) - LS-C37628 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-SORT1 / Sortilin Antibody (Extracellular Domain) - LS-C73437 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Sortilin Antibody [Unconjugated] - AF3154 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of human motor cortex. PVDF membrane was probed with 2 µg/mL of Goat Anti-Human Sortilin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF3154) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). A specific band was detected for Sortilin at approximately 95-105 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Sortilin Antibody (1B3) - H00006272-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B3
Western Blot: Sortilin Antibody (1B3) [H00006272-M01] - SORT1 monoclonal antibody (M01), clone 1B3. Analysis of SORT1 expression in human placenta.

Sortilin Antibody (334708) [Unconjugated] - MAB3154 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 334708
Simple Western lane view shows lysates of human brain (cerebellum) tissue, loaded at 0.2 mg/mL. A specific band was detected for Sortilin at approximately 87 kDa (as indicated) using 10 µg/mL of Mouse Anti-Human/Mouse/Rat Sortilin Monoclonal Antibody (Catalog # MAB3154). This experiment was conducted under reducing conditions and using the12-230 kDa separation system.

Sortilin Antibody - NBP1-89745 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Sortilin Antibody [NBP1-89745] - Analysis in human cell line SK-BR-3.

Sortilin Antibody - H00006272-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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