SORT1

Gene Symbol	SORT1
Entrez Gene	6272
Alt Symbol	Gp95, LDLCQ6, NT3
Species	Human
Gene Type	protein-coding
Description	sortilin 1
Other Description	100 kDa NT receptor|NTR3|glycoprotein 95|neurotensin receptor 3|sortilin
Swissprots	Q99523 Q8IZ49 C0JYZ0 B4DWI3
Accessions	ACN81319 CCF77015 EAW56380 Q99523 AA782785 AI623426 AI695671 AK000757 AK023648 AK129918 AK130545 AK293118 BAF85807 AK301548 BAG63045 AK310147 AL117561 AU132384 BC023542 AAH23542 BC041982 BC053575 BF591118 BQ001031 BQ774407 BX955818 CB267773 DA023768 DB045034 DQ896793 ABM87792 XM_005271100 XP_005271157 XM_005271101 XP_005271158 XM_005271102 XP_005271159 XM_006710812 XP_006710875 NM_001205228 NP_001192157 NM_002959 NP_002950
Function	Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|P
Subcellular Location	Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Tissue Specificity	Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:9013611}.
Top Pathways	Neurotrophin signaling pathway, Lysosome

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Sortilin peptide - ab16686 from Abcam Category Peptide

Human Sortilin protein fragment - ab114233 from Abcam Category Protein Source Wheat germ Species Human

SORT1 / Sortilin Blocking Peptide - LS-E23563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Sortilin Protein - H00006272-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Source Wheat Germ Species Human

SORT1-Antibody-Center-Blocking-peptide - BP11584c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Sortilin, CF - 3154-ST-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser78-Asn755, with a C-terminal 6-His tag

Neurotensin receptor 3 - H00006272-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Neurotensin receptor 3 - H00006272-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SORT1 fusion protein - Ag2997 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human SORT1 - SORT1-29618TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SORT1, GST-tagged - SORT1-2879H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Neurotensin Receptor 3/Sortilin - SORT1-15H from Creative Biomart Category Protein Source NSO Species Human

Neurotensin Receptor 3 (NTS3)/Sortilin, Carrier Free - PR15080CF-50 from Neuromics Category Protein Prices $315.00 Sizes 50 µg Species Human, Rat

Recombinant Sortilin 1 (SORT1) - RPC895Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Sortilin 1 (SORT1) - RPC895Mu61 from Uscn Life Science Inc. Category Protein Source HEK293 Species Mouse

Recombinant Human Sortilin(SORT1) - CSB-YP859102HU CSB-EP859102HU CSB-BP859102HU CSB-MP859102HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Sortilin Protein, CF - 3154-ST from R&D Systems Category Protein Prices $329.00 Sizes 50 µg Source Mouse myeloma cell line, NS0-derived Ser78-Asn755, with a C-terminal 6-His tag Species Human

SORT1 Protein - abx164080 from Abbexa Category Protein Species Human, Mouse

Sortilin 1 Protein (Recombinant) - abx167073 from Abbexa Category Protein Source Human Species Human

Sortilin Recombinant Protein Antigen - NBP1-89745PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SORT1 Peptide, Human - M34GP14898H from Creative Peptides Category Peptide Source Synthetic. Species Human

SORT1 Antibody - SH-A15879 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

Recombinant Sortilin 1 (SORT1) - RPU53421 from Biomatik Category Protein Prices $197.00, $403.00, $616.00, $734.72 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

SORT1 Recombinant Protein (OPCD07116) - OPCD07116 from Aviva Systems Biology Category Protein Source E.coli Species Human

Sortilin (SORT1), Recombinant Protein - MBS1289740 from MyBioSource Category Protein Prices $1,480.00, $1,480.00, $1,710.00, $1,710.00, $2,525.00, $2,525.00, $2,970.00, $2,970.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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