| Gene Symbol |
SORT1
|
| Entrez Gene |
6272
|
| Alt Symbol |
Gp95, LDLCQ6, NT3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sortilin 1
|
| Other Description |
100 kDa NT receptor|NTR3|glycoprotein 95|neurotensin receptor 3|sortilin
|
| Swissprots |
Q99523 Q8IZ49 C0JYZ0 B4DWI3
|
| Accessions |
ACN81319 CCF77015 EAW56380 Q99523 AA782785 AI623426 AI695671 AK000757 AK023648 AK129918 AK130545 AK293118 BAF85807 AK301548 BAG63045 AK310147 AL117561 AU132384 BC023542 AAH23542 BC041982 BC053575 BF591118 BQ001031 BQ774407 BX955818 CB267773 DA023768 DB045034 DQ896793 ABM87792 XM_005271100 XP_005271157 XM_005271101 XP_005271158 XM_005271102 XP_005271159 XM_006710812 XP_006710875 NM_001205228 NP_001192157 NM_002959 NP_002950
|
| Function |
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {ECO:0000269|PubMed:10085125, ECO:0000269|P
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Endosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Golgi apparatus, Golgi stack membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Nucleus membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
|
| Tissue Specificity |
Expressed in brain and prostate (at protein level). Expressed at high levels in brain, spinal cord, heart, skeletal muscle, thyroid, placenta and testis. Expressed at lower levels in lymphoid organs, kidney, colon and liver. {ECO:0000269|PubMed:20048080, ECO:0000269|PubMed:9013611}.
|
| Top Pathways |
Neurotrophin signaling pathway, Lysosome
|