Gene Symbol | KRT1 |
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Entrez Gene | 3848 |
Alt Symbol | CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK |
Species | Human |
Gene Type | protein-coding |
Description | keratin 1, type II |
Other Description | 67 kDa cytokeratin|CK-1|cytokeratin 1|cytokeratin-1|epidermolytic hyperkeratosis 1|hair alpha protein|keratin, type II cytoskeletal 1|type-II keratin Kb1 |
Swissprots | P86104 P85925 P04264 Q14720 Q9H298 Q6GSJ0 B2RA01 |
Accessions | AAB47721 AAF60327 AAG41947 AFA52002 AFA52003 AFA52004 AFA52005 AFA52006 AFA52007 CBX47449 EAW96642 P04264 AK313986 BAG36698 BC063697 AAH63697 DB112126 M10938 AAA36153 NM_006121 NP_006112 |
Function | May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein kinase C (RACK1/GNB2L1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK. {ECO:0000269|PubMed:17956333, ECO:0000269|PubMed:21544310}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:17956333}. Note=Located on plasma membrane of neuroblastoma NMB7 cells. |
Tissue Specificity | The source of this protein is neonatal foreskin. The 67-kDa type II keratins are expressed in terminally differentiating epidermis. |
Cytokeratin 1 CRISPR/Cas9 KO Plasmid (h) - sc-400893 from Santa Cruz Biotechnology
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Cytokeratin 1 HDR Plasmid (h) - sc-400893-HDR from Santa Cruz Biotechnology
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Cytokeratin 1 Double Nickase Plasmid (h) - sc-400893-NIC from Santa Cruz Biotechnology
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Cytokeratin 1 Double Nickase Plasmid (h2) - sc-400893-NIC-2 from Santa Cruz Biotechnology
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Cytokeratin 1 CRISPR Activation Plasmid (h) - sc-400893-ACT from Santa Cruz Biotechnology
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Cytokeratin 1 CRISPR Activation Plasmid (h2) - sc-400893-ACT-2 from Santa Cruz Biotechnology
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Cytokeratin 1 Lentiviral Activation Particles (h) - sc-400893-LAC from Santa Cruz Biotechnology
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Cytokeratin 1 Lentiviral Activation Particles (h2) - sc-400893-LAC-2 from Santa Cruz Biotechnology
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Cytokeratin 1 siRNA (h) - sc-43285 from Santa Cruz Biotechnology
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Cytokeratin 1 shRNA Plasmid (h) - sc-43285-SH from Santa Cruz Biotechnology
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Cytokeratin 1 shRNA (h) Lentiviral Particles - sc-43285-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN11355 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11355 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04656 from Sigma-Aldrich
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KRT1 siRNA (Human) - CRH2609 from Cohesion Biosciences
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Cytokeratin 1 RNAi - H00003848-R02 from Novus Biologicals
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shRNA set against Human KRT1 (NM_006121.3) - SHH327195 from Creative biogene
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shRNA set against Human KRT1(NM_006121.3) - SHL205032 from Creative biogene
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KRT1 shRNA Plasmid (Human) - CHH2609 from Cohesion Biosciences
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KRT1 miRNA 3'UTR clone - MiUTR1H-05438 from Creative biogene
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