RNF128

Gene Symbol	RNF128
Entrez Gene	79589
Alt Symbol	GRAIL
Species	Human
Gene Type	protein-coding
Description	ring finger protein 128, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF128|gene related to anergy in lymphocytes protein
Swissprots	A0PJI4 Q6PH80 Q9H5E4 Q6ZTJ8 Q8TEB7 Q96RF3
Accessions	EAX02737 Q8TEB7 AF394689 AAK77554 AK027169 BAB15682 AK074264 BAB85033 AK126553 BAC86589 BC012931 BC030951 AAH30951 BC036901 BC056677 AAH56677 BC063404 AAH63404 BI600046 HQ448134 ADQ32615 NM_024539 NP_078815 NM_194463 NP_919445
Function	E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys- 48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}.
Subcellular Location	Endomembrane system {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GRAIL (E-13) - sc-132301 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GRAIL (S-15) - sc-132302 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GRAIL (C-14) - sc-132300 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GRAIL (H-91) - sc-292308 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

GRAIL (M-17) - sc-101967 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-RNF128 antibody - ab139066 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 antibody [EPR7426(2)] - ab137088 from Abcam Prices $381.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7426(2)

Anti-RNF128 / GRAIL Antibody (C-Terminus) - LS-C31988 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, AP) - LS-C240067 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, APC) - LS-C240068 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, Biotin) - LS-C240069 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, FITC) - LS-C240070 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, PE) - LS-C240073 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa289-338) - LS-C135488 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143) - LS-C324719 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143) - LS-C158863 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa227-253) - LS-C47370 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-RNF128 / GRAIL Antibody (aa115-143, Azide-free, HRP) - LS-C248015 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

GRAIL/RNF128 Antibody - NBP2-24610 from Novus Biologicals Prices $99.00, $279.00 Sizes 25 µg, 100 µg Host Rabbit Clonality Polyclonal

GRAIL/RNF128 Antibody - AF6234 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Sheep Clonality Polyclonal

GRAIL/RNF128 Antibody - NBP2-13237 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

GRAIL/RNF128 Antibody - NBP1-69426 from Novus Biologicals Prices $299.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

RNF128 Polyclonal Antibody - bs-9251R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 antibody produced in rabbit - SAB2107364 from Sigma-Aldrich Prices $341.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-RNF128 antibody produced in rabbit - AV43311 from Sigma-Aldrich Prices $267.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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