RNF128

Gene Symbol	RNF128
Entrez Gene	79589
Alt Symbol	GRAIL
Species	Human
Gene Type	protein-coding
Description	ring finger protein 128, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase RNF128|gene related to anergy in lymphocytes protein
Swissprots	A0PJI4 Q6PH80 Q9H5E4 Q6ZTJ8 Q8TEB7 Q96RF3
Accessions	EAX02737 Q8TEB7 AF394689 AAK77554 AK027169 BAB15682 AK074264 BAB85033 AK126553 BAC86589 BC012931 BC030951 AAH30951 BC036901 BC056677 AAH56677 BC063404 AAH63404 BI600046 HQ448134 ADQ32615 NM_024539 NP_078815 NM_194463 NP_919445
Function	E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys- 48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}.
Subcellular Location	Endomembrane system {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF128 full length protein - ab164040 from Abcam Category Protein Source Wheat germ Species Human

Human RNF128 protein fragment - ab164041 from Abcam Category Protein Source Wheat germ Species Human

RNF128 / GRAIL Antibody Blocking Peptide - LS-E6572 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF128 / GRAIL Antibody Blocking Peptide - LS-E21625 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GRAIL/RNF128 Protein - H00079589-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human GRAIL/RNF128 Protein - H00079589-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF128-Antibody-Center-Blocking-Peptide - BP19347c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF128 Blocking Peptide - 33R-4889 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF128 Blocking Peptide - 33R-7219 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF128 - H00079589-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF128 - H00079589-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF128 - H00079589-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF128 - H00079589-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF128 fusion protein - Ag22834 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

GRAIL/RNF128 Recombinant Protein Antigen - NBP2-13237PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF128 Peptide, Human - M34GP13379H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RNF128 (RNF128), Recombinant Protein - MBS7028721 from MyBioSource Category Protein Prices $1,195.00, $2,180.00, $3,390.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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