| Gene Symbol | RNF128 |
|---|---|
| Entrez Gene | 79589 |
| Alt Symbol | GRAIL |
| Species | Human |
| Gene Type | protein-coding |
| Description | ring finger protein 128, E3 ubiquitin protein ligase |
| Other Description | E3 ubiquitin-protein ligase RNF128|gene related to anergy in lymphocytes protein |
| Swissprots | A0PJI4 Q6PH80 Q9H5E4 Q6ZTJ8 Q8TEB7 Q96RF3 |
| Accessions | EAX02737 Q8TEB7 AF394689 AAK77554 AK027169 BAB15682 AK074264 BAB85033 AK126553 BAC86589 BC012931 BC030951 AAH30951 BC036901 BC056677 AAH56677 BC063404 AAH63404 BI600046 HQ448134 ADQ32615 NM_024539 NP_078815 NM_194463 NP_919445 |
| Function | E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys- 48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals. {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. |
| Subcellular Location | Endomembrane system {ECO:0000250}; Single- pass membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12705856, ECO:0000269|PubMed:22016387}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7A (By similarity). {ECO:0000250}. |