IRAK4

Gene Symbol	IRAK4
Entrez Gene	51135
Alt Symbol	IPD1, IRAK-4, NY-REN-64, REN64
Species	Human
Gene Type	protein-coding
Description	interleukin-1 receptor-associated kinase 4
Other Description	renal carcinoma antigen NY-REN-64
Swissprots	Q9Y589 Q9NWZ3 Q8TDF7 Q69FE1
Accessions	AAN75440 CAD37279 EAW57867 Q9NWZ3 AF155118 AAD42884 AF445802 AAM15772 AI126481 AK000528 BAA91232 AK027301 AK299944 BAG61774 AK304583 BAG65371 AK314288 BAG36946 AY283670 AAP57089 AY283671 AAP57090 AY340962 AAR02358 AY340963 AAR02359 AY340964 AAR02360 AY340965 AAR02361 AY340966 AAR02362 AY340967 AAR02363 AY730682 AAX22228 BC013316 AAH13316 DA290809 DQ892885 ABM83811 DQ896134 ABM87133 LK938723 XM_005268943 XP_005269000 XM_005268944 XP_005269001 XM_005268945 XP_005269002 XM_005268946 XP_005269003 XM_005268947 XP_005269004 XM_005268948 XP_005269005 XM_005268949 XP_005269006 XM_006719438 XP_006719501 XM_006719439 XP_006719502 XM_006719440 XP_006719503 XM_006719441 XP_006719504 XM_006719442 XP_006719505 XM_006719443 XP_006719506 XM_011538431 XP_011536733 XM_011538432 XP_011536734 XM_011538433 XP_011536735 NM_001114182 NP_001107654 NM_001145256 NP_001138728 NM_001145257 NP_001138729 NM_001145258 NP_001138730 NM_016123 NP_057207
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21325272}.
Top Pathways	Toxoplasmosis, Tuberculosis, Influenza A, Measles, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total IRAK4 Sandwich ELISA Kit - 13336 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

HTScan® IRAK4 Kinase Assay Kit - 7552 from Cell Signaling Technology Category Assay Kit

Human IRAK4 / IRAK-4 ELISA Kit (Sandwich ELISA) - LS-F4782 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Rat IRAK4 / IRAK-4 ELISA Kit (Sandwich ELISA) - LS-F8523 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 5.9 pg/ml Range 1.56-100 ng/ml

Human IRAK4 ELISA Kit - abx152056 from Abbexa Category ELISA Kit Sensitivity 0.54 ng/ml Range 1.563 ng/ml - 100 ng/ml

Interleukin 1 Receptor Associated Kinase 4 (IRAK4), Human, ELISA Kit - SEB518Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.53ng/mL Range 1.56-100ng/mL

Interleukin-1 receptor-associated kinase 4 (IRAK-4), Human, ELISA Kit - CSB-E16338h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Interleukin 1 Receptor Associated Kinase 4 (IRAK4), ELISA Kit - MBS2023519 from MyBioSource Category ELISA Kit Prices $355.00, $540.00, $730.00, $2,985.00, $5,410.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.54ng/mL. Range 1.56-100ng/mL

Interleukin 1 Receptor Associated Kinase 4 (IRAK4), ELISA Kit - MBS2021534 from MyBioSource Category ELISA Kit Prices $390.00, $580.00, $785.00, $3,220.00, $5,840.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 5.9pg/mL. Range 15.63-1000pg/mL

interleukin-1 receptor-associated kinase 4, ELISA Kit - MBS705939 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.56 pg/ml. Range 6.25 pg/ml -400 pg/ml.

ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) - SEB518Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL. Range 1.56-100ng/mL The standard curve concentrations used for the ELISA’s were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.13ng/mL, 1.56ng/mL

ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) - SEB518Ra from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 5.9pg/mL. Range 15.63-1000pg/mL The standard curve concentrations used for the ELISA’s were 1000pg/mL, 500pg/mL, 250pg/mL, 125pg/mL, 62.5pg/mL, 31.25pg/mL, 15.63pg/mL

Human interleukin-1 receptor-associated kinase 4(IRAK-4)ELISA Kit - CSB-E16338h from Cusabio Category ELISA Kit Sensitivity 1.56 pg/ml Range 6.25 pg/ml-400 pg/ml

ELISA Kit for Interleukin 1 Receptor Associated Kinase 4 (IRAK4) - SEB518Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.54ng/mL. Range 1.563-100ng/mL The standard curve concentrations used for the ELISA's were 100ng/mL, 50ng/mL, 25ng/mL, 12.5ng/mL, 6.25ng/mL, 3.125ng/mL, 1.563ng/mL

Interleukin 1 Receptor Associated Kinase 4 (IRAK4), Human, ELISA Kit - DL-IRAK4-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 1.56-100 ng/mL

Human IRAK4 ELISA Kit - abx573811 from Abbexa Category ELISA Kit Sensitivity 0.53 ng/ml Range 1.563 ng/ml - 100 ng/ml

Human interleukin-1 receptor-associated kinase 4 (IRAK-4) ELISA Kit - EKC34261 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 1.56 pg/ml Range 6.25 pg/ml-400 pg/ml

Human IRAK4 ELISA Kit - E020451 from Biobool Category ELISA Kit Sensitivity Typically less than 0.54ng/mL.

Human IRAK-4 ELISA Kit - E020816 from Biobool Category ELISA Kit Sensitivity 0.54 ng/mL

IRAK4 ELISA Kit (Human) (OKCD00674) - OKCD00674 from Aviva Systems Biology Category ELISA Kit Prices $525.00 Sizes 96 wells Sensitivity < 0.64 ng/mL Range 1.56-100 ng/mL

anti-IRAK4 antibody - ARG54631 from Arigo Biolaboratories Category ELISA Kit

anti-IRAK4 antibody - ARG63779 from Arigo Biolaboratories Category ELISA Kit

Interleukin 1 Receptor Associated Kinase 4 (IRAK4), ELISA Kit - MBS454826 from MyBioSource Category ELISA Kit Prices $360.00, $475.00, $2,045.00, $3,960.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.53ng/mL Range 1.56-100ng/mL

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