| Gene Symbol | IRAK4 |
|---|---|
| Entrez Gene | 51135 |
| Alt Symbol | IPD1, IRAK-4, NY-REN-64, REN64 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin-1 receptor-associated kinase 4 |
| Other Description | renal carcinoma antigen NY-REN-64 |
| Swissprots | Q9Y589 Q9NWZ3 Q8TDF7 Q69FE1 |
| Accessions | AAN75440 CAD37279 EAW57867 Q9NWZ3 AF155118 AAD42884 AF445802 AAM15772 AI126481 AK000528 BAA91232 AK027301 AK299944 BAG61774 AK304583 BAG65371 AK314288 BAG36946 AY283670 AAP57089 AY283671 AAP57090 AY340962 AAR02358 AY340963 AAR02359 AY340964 AAR02360 AY340965 AAR02361 AY340966 AAR02362 AY340967 AAR02363 AY730682 AAX22228 BC013316 AAH13316 DA290809 DQ892885 ABM83811 DQ896134 ABM87133 LK938723 XM_005268943 XP_005269000 XM_005268944 XP_005269001 XM_005268945 XP_005269002 XM_005268946 XP_005269003 XM_005268947 XP_005269004 XM_005268948 XP_005269005 XM_005268949 XP_005269006 XM_006719438 XP_006719501 XM_006719439 XP_006719502 XM_006719440 XP_006719503 XM_006719441 XP_006719504 XM_006719442 XP_006719505 XM_006719443 XP_006719506 XM_011538431 XP_011536733 XM_011538432 XP_011536734 XM_011538433 XP_011536735 NM_001114182 NP_001107654 NM_001145256 NP_001138728 NM_001145257 NP_001138729 NM_001145258 NP_001138730 NM_016123 NP_057207 |
| Function | Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase a |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:21325272}. |
| Top Pathways | Toxoplasmosis, Tuberculosis, Influenza A, Measles, Pertussis |