IRAK4

Gene Symbol	IRAK4
Entrez Gene	51135
Alt Symbol	IPD1, IRAK-4, NY-REN-64, REN64
Species	Human
Gene Type	protein-coding
Description	interleukin-1 receptor-associated kinase 4
Other Description	renal carcinoma antigen NY-REN-64
Swissprots	Q9Y589 Q9NWZ3 Q8TDF7 Q69FE1
Accessions	AAN75440 CAD37279 EAW57867 Q9NWZ3 AF155118 AAD42884 AF445802 AAM15772 AI126481 AK000528 BAA91232 AK027301 AK299944 BAG61774 AK304583 BAG65371 AK314288 BAG36946 AY283670 AAP57089 AY283671 AAP57090 AY340962 AAR02358 AY340963 AAR02359 AY340964 AAR02360 AY340965 AAR02361 AY340966 AAR02362 AY340967 AAR02363 AY730682 AAX22228 BC013316 AAH13316 DA290809 DQ892885 ABM83811 DQ896134 ABM87133 LK938723 XM_005268943 XP_005269000 XM_005268944 XP_005269001 XM_005268945 XP_005269002 XM_005268946 XP_005269003 XM_005268947 XP_005269004 XM_005268948 XP_005269005 XM_005268949 XP_005269006 XM_006719438 XP_006719501 XM_006719439 XP_006719502 XM_006719440 XP_006719503 XM_006719441 XP_006719504 XM_006719442 XP_006719505 XM_006719443 XP_006719506 XM_011538431 XP_011536733 XM_011538432 XP_011536734 XM_011538433 XP_011536735 NM_001114182 NP_001107654 NM_001145256 NP_001138728 NM_001145257 NP_001138729 NM_001145258 NP_001138730 NM_016123 NP_057207
Function	Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase a
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:21325272}.
Top Pathways	Toxoplasmosis, Tuberculosis, Influenza A, Measles, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IRAK-4 CRISPR/Cas9 KO Plasmid (h) - sc-416405 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 HDR Plasmid (h) - sc-416405-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 Double Nickase Plasmid (h) - sc-416405-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 Double Nickase Plasmid (h2) - sc-416405-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 CRISPR Activation Plasmid (h) - sc-416405-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 CRISPR Activation Plasmid (h2) - sc-416405-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 Lentiviral Activation Particles (h) - sc-416405-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 Lentiviral Activation Particles (h2) - sc-416405-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

IRAK-4 siRNA (h) - sc-45400 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK-4 shRNA Plasmid (h) - sc-45400-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK-4 shRNA (h) Lentiviral Particles - sc-45400-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IRAK4 RNAi - H00051135-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU145781 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0982 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0985 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0983 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0984 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0986 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0987 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1270 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1270 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09391 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09391

IRAK4 siRNA (Human) - CRH9554 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IRAK4 - MBS828407 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IRAK4 (NM_016123.3) - SHH320533 from Creative biogene Category siRNA Species Reactivities Human

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