POLK

Gene Symbol POLK
Entrez Gene 51426
Alt Symbol DINB1, DINP, POLQ
Species Human
Gene Type protein-coding
Description polymerase (DNA directed) kappa
Other Description DNA polymerase kappa
Swissprots Q96Q87 Q96L01 Q8IZY0 B2RBD2 Q96Q86 Q5Q9G6 Q8NB30 Q5Q9G5 Q86VJ8 Q9UBT6 Q8IZY1 Q5Q9G7 Q9UHC5 Q5Q9G8
Accessions AAP12648 BAB58975 BAB58976 CCQ43535 EAW95762 EAW95763 EAW95764 EAW95765 Q9UBT6 AB027564 BAA86943 AB209291 BAD92528 AF163570 AAF02540 AF194973 AAF23270 AF315601 AF315602 AAN15780 AF318313 AAN15781 AK026316 AK091659 BAC03714 AK314610 BAG37179 AY769929 AAV80827 AY769930 AAV80828 AY769931 AAV80829 AY769932 AAV80830 BC014955 AAH14955 BC041798 BC050718 AAH50718 XM_005248534 XP_005248591 XM_005248536 XP_005248593 XM_006714652 XP_006714715 XM_011543463 XP_011541765 XM_011543464 XP_011541766 XM_011543465 XP_011541767 XM_011543466 XP_011541768 XM_011543467 XP_011541769 XM_011543468 XP_011541770 XR_241783 XR_241784 XR_948273 NM_016218 NP_057302
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269|PubMed:10620008, ECO:0000269|PubMed:11024016, ECO:0000269|PubMed:12145297, ECO:0000269|PubMed:12444249, ECO:0000269|PubMed:12952891, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15533436}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12414988}. Note=Detected throughout the nucleus and at replication foci.
Tissue Specificity Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:10518552, ECO:0000269|PubMed:10620008}.
Top Pathways Fanconi anemia pathway

POLK 293T Cell Transient Overexpression Lysate(Denatured) - H00051426-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

POLK 293 Cell Lysate - 406781 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

DNA Polymerase Kappa Overexpression Lysate (Denatured) - H00051426-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
POLK transfected lysate.

DNA Polymerase Kappa Overexpression Lysate (Native) - NBP2-07070 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: DNA Polymerase Kappa Overexpression Lysate (Adult Normal) [NBP2-07070] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DNA Polymerase Kappa.

DinB (h): 293T Lysate - sc-116324 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

POLK Over-expression Lysate Product - GWB-BEF465 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

DNA Polymerase Kappa Overexpression Lysate (Denatured) - H00051426-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

POLK knockout Cell lysate - LC810712 from Acris Antibodies

Category Cell Lysate
Prices $495.00
Sizes 100 µg

Panoply™ Human POLK Knockdown Stable Cell Line - CSC-DC012079 from Creative biogene

Category Cell Line
Species Human

Human POLK Knockout Cell Line-HeLa - CSC-RT0780 from Creative biogene

Category Cell Line
Species Human
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