POLK

Gene Symbol	POLK
Entrez Gene	51426
Alt Symbol	DINB1, DINP, POLQ
Species	Human
Gene Type	protein-coding
Description	polymerase (DNA directed) kappa
Other Description	DNA polymerase kappa
Swissprots	Q96Q87 Q96L01 Q8IZY0 B2RBD2 Q96Q86 Q5Q9G6 Q8NB30 Q5Q9G5 Q86VJ8 Q9UBT6 Q8IZY1 Q5Q9G7 Q9UHC5 Q5Q9G8
Accessions	AAP12648 BAB58975 BAB58976 CCQ43535 EAW95762 EAW95763 EAW95764 EAW95765 Q9UBT6 AB027564 BAA86943 AB209291 BAD92528 AF163570 AAF02540 AF194973 AAF23270 AF315601 AF315602 AAN15780 AF318313 AAN15781 AK026316 AK091659 BAC03714 AK314610 BAG37179 AY769929 AAV80827 AY769930 AAV80828 AY769931 AAV80829 AY769932 AAV80830 BC014955 AAH14955 BC041798 BC050718 AAH50718 XM_005248534 XP_005248591 XM_005248536 XP_005248593 XM_006714652 XP_006714715 XM_011543463 XP_011541765 XM_011543464 XP_011541766 XM_011543465 XP_011541767 XM_011543466 XP_011541768 XM_011543467 XP_011541769 XM_011543468 XP_011541770 XR_241783 XR_241784 XR_948273 NM_016218 NP_057302
Function	DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269|PubMed:10620008, ECO:0000269|PubMed:11024016, ECO:0000269|PubMed:12145297, ECO:0000269|PubMed:12444249, ECO:0000269|PubMed:12952891, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15533436}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:12414988}. Note=Detected throughout the nucleus and at replication foci.
Tissue Specificity	Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:10518552, ECO:0000269|PubMed:10620008}.
Top Pathways	Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human DNA Polymerase Kappa/POLK protein fragment - ab176956 from Abcam Category Protein Prices $490.00 Sizes 50 µg Source E. coli Species Human

Human DNA Polymerase Kappa/POLK full length protein - ab132048 from Abcam Category Protein Source Wheat germ Species Human

POLQ / DNA Polymerase Theta Antibody Blocking Peptide - LS-E26693 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human DNA polymerase theta Protein - H00010721-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

POLQ Blocking Peptide - 33R-8319 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DNA polymerase kappa - H00051426-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DNA polymerase kappa - H00051426-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

POLK fusion protein - Ag6034 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

POLK fusion protein - Ag6194 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human POLK Protein, His-tagged - POLK-763H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human POLK, GST-tagged - POLK-765H from Creative Biomart Category Protein Source wheat germ Species Human

Recombinant Human POLK, GST-tagged - POLK-1835H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human POLK, MYC/DDK-tagged - POLK-837H from Creative Biomart Category Protein Source HEK293 Species Human

Recombinant Human POLK, His-tagged - POLK-838H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DNA polymerase kappa - POLK-137H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DNA polymerase kappa(POLK) ,partial - CSB-YP887009HU CSB-EP887009HU CSB-BP887009HU CSB-MP887009HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DNA polymerase kappa - TP319806 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

POLK-Blocking-Peptide-Center - BP19981c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

POLQ Peptide, Human - M34GP12083H from Creative Peptides Category Peptide Source Synthetic. Species Human

DNA polymerase kappa (POLK), partial, Recombinant Protein - MBS1402633 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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