POLK

Gene Symbol POLK
Entrez Gene 51426
Alt Symbol DINB1, DINP, POLQ
Species Human
Gene Type protein-coding
Description polymerase (DNA directed) kappa
Other Description DNA polymerase kappa
Swissprots Q96Q87 Q96L01 Q8IZY0 B2RBD2 Q96Q86 Q5Q9G6 Q8NB30 Q5Q9G5 Q86VJ8 Q9UBT6 Q8IZY1 Q5Q9G7 Q9UHC5 Q5Q9G8
Accessions AAP12648 BAB58975 BAB58976 CCQ43535 EAW95762 EAW95763 EAW95764 EAW95765 Q9UBT6 AB027564 BAA86943 AB209291 BAD92528 AF163570 AAF02540 AF194973 AAF23270 AF315601 AF315602 AAN15780 AF318313 AAN15781 AK026316 AK091659 BAC03714 AK314610 BAG37179 AY769929 AAV80827 AY769930 AAV80828 AY769931 AAV80829 AY769932 AAV80830 BC014955 AAH14955 BC041798 BC050718 AAH50718 XM_005248534 XP_005248591 XM_005248536 XP_005248593 XM_006714652 XP_006714715 XM_011543463 XP_011541765 XM_011543464 XP_011541766 XM_011543465 XP_011541767 XM_011543466 XP_011541768 XM_011543467 XP_011541769 XM_011543468 XP_011541770 XR_241783 XR_241784 XR_948273 NM_016218 NP_057302
Function DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Depending on the context, it inserts the correct base, but causes frequent base transitions, transversions and frameshifts. Lacks 3'-5' proofreading exonuclease activity. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but does not have lyase activity. {ECO:0000269|PubMed:10620008, ECO:0000269|PubMed:11024016, ECO:0000269|PubMed:12145297, ECO:0000269|PubMed:12444249, ECO:0000269|PubMed:12952891, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15533436}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12414988}. Note=Detected throughout the nucleus and at replication foci.
Tissue Specificity Detected at low levels in testis, spleen, prostate and ovary. Detected at very low levels in kidney, colon, brain, heart, liver, lung, placenta, pancreas and peripheral blood leukocytes. {ECO:0000269|PubMed:10518552, ECO:0000269|PubMed:10620008}.
Top Pathways Fanconi anemia pathway

DinB (A-9) - sc-166667 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DinB (A-9): sc-166667. Western blot analysis of DinB expression in F9 (A), PC-12 (B), DU 145 (C) and COLO 320DM (D) whole cell lysates and HeLa nuclear extract (E).

DinB (H-180) - sc-67349 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DinB (H-180): sc-67349. Western blot analysis of human recombinant DinB fusion protein.

DinB (D-20) - sc-51064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-DNA Polymerase Kappa/POLK antibody - ab57070 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-DNA Polymerase Kappa/POLK antibody (ab57070) at 1 µg + HeLa nuclear lysate at 25 µgSecondaryGoat Anti-Mouse IgG at 1/5000 dilution

Anti-DNA Polymerase Kappa/POLK antibody - ab115625 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab115625, at 5 µg/ml, staining DNA Polymerase Kappa/POLK in formalin fixed, paraffin embedded Human prostate tissue by Immunohistochemistry. Following primary incubation slides were incubated with biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-DNA Polymerase Kappa/POLK antibody - ab75794 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DNA Polymerase Kappa/POLK antibody (ab75794) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DNA Polymerase Kappa/POLK antibody - ab90020 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DNA Polymerase Kappa/POLK antibody (ab90020) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal kidney lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-DNA Polymerase Kappa/POLK antibody - ab156184 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DNA Polymerase Kappa/POLK antibody (ab156184) at 1/100 dilution + 293 cell lysate at 35 µg

Anti-DNA Polymerase Kappa/POLK antibody - ab86076 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DNA Polymerase Kappa/POLK antibody (ab86076) at 0.04 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : HeLa whole cell lysate at 5 µgLane 4 : 293T whole cell lysate at 50 µg

Anti-POLK / DNA Polymerase Kappa Antibody (aa817-830) IHC-plus™ - LS-B405 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-POLK antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B405 concentration 5 ug/ml.

Anti-POLK / DNA Polymerase Kappa Antibody (clone 6F2) IHC-plus™ - LS-B5464 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 6F2
Anti-POLK antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5464 concentration 5 ug/ml.

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, AP) - LS-C239273 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, FITC) - LS-C239275 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, APC) - LS-C239274 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, Biotin) - LS-C239276 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, PE) - LS-C239281 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560, Azide-free, HRP) - LS-C248519 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa825-870) - LS-C288736 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK Antibody (aa775-825) - LS-C288734 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK Antibody (aa1-473, Azide-free) - LS-C328289 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa531-560) - LS-C324163 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa675-725) - LS-C288737 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody - LS-C342264 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-POLK / DNA Polymerase Kappa Antibody (aa542-591) - LS-C81298 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-POLK / DNA Polymerase Kappa Antibody (aa35-84) - LS-C111194 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
POLK antibody LS-C111194 Western blot of Fetal Kidney lysate.
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