| Gene Symbol |
GAR1
|
| Entrez Gene |
54433
|
| Alt Symbol |
NOLA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GAR1 ribonucleoprotein
|
| Other Description |
GAR1 ribonucleoprotein homolog|H/ACA ribonucleoprotein complex subunit 1|nucleolar protein family A member 1|nucleolar protein family A, member 1 (H/ACA small nucleolar RNPs)|snoRNP protein GAR1
|
| Swissprots |
Q5MJQ2 Q9NY12
|
| Accessions |
EAX06253 EAX06254 Q9NY12 AA311919 AJ276003 CAB76563 AK310489 AY780787 AAV98357 BC003413 AAH03413 CN428426 DQ894157 ABM85083 EU176271 ABW03722 NM_018983 NP_061856 NM_032993 NP_127460
|
| Function |
Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:10757788, ECO:0000269|PubMed:15044956}.
|
| Subcellular Location |
Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
|
| Top Pathways |
Ribosome biogenesis in eukaryotes
|