Gene Symbol | FMO2 |
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Entrez Gene | 2327 |
Alt Symbol | FMO1B1 |
Species | Human |
Gene Type | protein-coding |
Description | flavin containing monooxygenase 2 (non-functional) |
Other Description | FMO, pulmonary|dimethylaniline monooxygenase [N-oxide-forming] 2|dimethylaniline oxidase 2|pulmonary flavin-containing monooxygenase 2 |
Swissprots | Q9BRX1 Q86U73 Q5EBX4 Q99518 |
Accessions | AAW82431 EAW90889 Q99518 AI821378 AK098145 AK304385 BAG65221 AK312877 BAG35728 AL833218 CAI46191 BC005894 AAH05894 BI766311 BT006979 AAP35625 CA312067 DB224311 DB236882 DQ893533 ABM84459 DQ893748 ABM84674 R95468 Y09267 CAA70462 XR_426768 XR_921761 NM_001301347 NP_001288276 NM_001460 NP_001451 |
Function | Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. {ECO:0000269|PubMed:9804831}. |
Subcellular Location | Microsome membrane. Endoplasmic reticulum membrane. |
Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}. |
Top Pathways | Drug metabolism - cytochrome P450 |
FMO2 (C-12) - sc-83826 from Santa Cruz Biotechnology
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FMO2 (H-53) - sc-368163 from Santa Cruz Biotechnology
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FMO2 (L-12) - sc-83827 from Santa Cruz Biotechnology
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Anti-FMO2 antibody - ab95977 from Abcam
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Anti-FMO2 antibody - ab171907 from Abcam
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Anti-FMO2 Antibody - LS-C310378 from LifeSpan Bioscience
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Anti-FMO2 Antibody (aa102-151) - LS-C135948 from LifeSpan Bioscience
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Anti-FMO2 Antibody (aa74-354) - LS-C186110 from LifeSpan Bioscience
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FMO2 Antibody - NBP1-85952 from Novus Biologicals
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FMO2 Antibody - NBP1-33318 from Novus Biologicals
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FMO2 Antibody - H00002327-D01P from Novus Biologicals
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Anti-FMO2 antibody produced in rabbit - HPA028261 from Sigma-Aldrich
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Anti-FMO2 antibody produced in rabbit - SAB2701055 from Sigma-Aldrich
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FMO2 antibody - N-terminal region (ARP61234_P050) - ARP61234_P050 from Aviva Systems Biology
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FMO2 antibody [N1C2] - GTX109907 from GeneTex
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FMO4 antibody, N-term - GTX46568 from GeneTex
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FMO2 antibody - orb69668 from Biorbyt
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FMO2 antibody - 70R-13320 from Fitzgerald
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) - 126906 from USBiological Life Science
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) (AP) - 126906-AP from USBiological Life Science
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) (Biotin) - 126906-Biotin from USBiological Life Science
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) (FITC) - 126906-FITC from USBiological Life Science
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) (HRP) - 126906-HRP from USBiological Life Science
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Anti -FMO2 (Dimethylaniline Monooxygenase [N-oxide-forming] 2, Pulmonary Flavin-containingMonooxygenase 2, FMO 2, FMO 1B1, Dimethylaniline Oxidase 2) (PE) - 126906-PE from USBiological Life Science
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Anti -FMO2 (Pulmonary Flavin-containing Monooxygenase 2, FMO 2, FMO1B1, FMO 1B1) - 210869 from USBiological Life Science
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