Gene Symbol | FMO2 |
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Entrez Gene | 2327 |
Alt Symbol | FMO1B1 |
Species | Human |
Gene Type | protein-coding |
Description | flavin containing monooxygenase 2 (non-functional) |
Other Description | FMO, pulmonary|dimethylaniline monooxygenase [N-oxide-forming] 2|dimethylaniline oxidase 2|pulmonary flavin-containing monooxygenase 2 |
Swissprots | Q9BRX1 Q86U73 Q5EBX4 Q99518 |
Accessions | AAW82431 EAW90889 Q99518 AI821378 AK098145 AK304385 BAG65221 AK312877 BAG35728 AL833218 CAI46191 BC005894 AAH05894 BI766311 BT006979 AAP35625 CA312067 DB224311 DB236882 DQ893533 ABM84459 DQ893748 ABM84674 R95468 Y09267 CAA70462 XR_426768 XR_921761 NM_001301347 NP_001288276 NM_001460 NP_001451 |
Function | Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. {ECO:0000269|PubMed:9804831}. |
Subcellular Location | Microsome membrane. Endoplasmic reticulum membrane. |
Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}. |
Top Pathways | Drug metabolism - cytochrome P450 |
FMO2 CRISPR/Cas9 KO Plasmid (h) - sc-408437 from Santa Cruz Biotechnology
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FMO2 HDR Plasmid (h) - sc-408437-HDR from Santa Cruz Biotechnology
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FMO2 Double Nickase Plasmid (h) - sc-408437-NIC from Santa Cruz Biotechnology
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FMO2 Double Nickase Plasmid (h2) - sc-408437-NIC-2 from Santa Cruz Biotechnology
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FMO2 CRISPR Activation Plasmid (h) - sc-408437-ACT from Santa Cruz Biotechnology
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FMO2 CRISPR Activation Plasmid (h2) - sc-408437-ACT-2 from Santa Cruz Biotechnology
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FMO2 Lentiviral Activation Particles (h) - sc-408437-LAC from Santa Cruz Biotechnology
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FMO2 Lentiviral Activation Particles (h2) - sc-408437-LAC-2 from Santa Cruz Biotechnology
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FMO2 siRNA (h) - sc-75043 from Santa Cruz Biotechnology
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FMO2 shRNA Plasmid (h) - sc-75043-SH from Santa Cruz Biotechnology
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FMO2 shRNA (h) Lentiviral Particles - sc-75043-V from Santa Cruz Biotechnology
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FMO2 RNAi - H00002327-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015031 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8841 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR14173 from Sigma-Aldrich
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FMO2 siRNA (Human) - CRH1630 from Cohesion Biosciences
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FMO2 - MBS8234953 from MyBioSource
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shRNA set against Human FMO2 (NM_001460.2) - SHH295906 from Creative biogene
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shRNA set against Human FMO2(NM_001460.2) - SHH063983 from Creative biogene
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FMO2 shRNA Plasmid (Human) - CHH1630 from Cohesion Biosciences
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FMO2 miRNA 3'UTR clone - MiUTR1H-03782 from Creative biogene
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