Gene Symbol | FMO2 |
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Entrez Gene | 2327 |
Alt Symbol | FMO1B1 |
Species | Human |
Gene Type | protein-coding |
Description | flavin containing monooxygenase 2 (non-functional) |
Other Description | FMO, pulmonary|dimethylaniline monooxygenase [N-oxide-forming] 2|dimethylaniline oxidase 2|pulmonary flavin-containing monooxygenase 2 |
Swissprots | Q9BRX1 Q86U73 Q5EBX4 Q99518 |
Accessions | AAW82431 EAW90889 Q99518 AI821378 AK098145 AK304385 BAG65221 AK312877 BAG35728 AL833218 CAI46191 BC005894 AAH05894 BI766311 BT006979 AAP35625 CA312067 DB224311 DB236882 DQ893533 ABM84459 DQ893748 ABM84674 R95468 Y09267 CAA70462 XR_426768 XR_921761 NM_001301347 NP_001288276 NM_001460 NP_001451 |
Function | Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. {ECO:0000269|PubMed:9804831}. |
Subcellular Location | Microsome membrane. Endoplasmic reticulum membrane. |
Tissue Specificity | Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}. |
Top Pathways | Drug metabolism - cytochrome P450 |
Human FMO2 full length protein - ab158456 from Abcam
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FMO2 Antibody Blocking Peptide - LS-E22394 from LifeSpan Bioscience
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Recombinant Human FMO2 Protein - H00002327-P01 from Novus Biologicals
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FMO2 - H00002327-P01-10 from Acris Antibodies
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FMO2 - H00002327-P01-25 from Acris Antibodies
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FMO2 fusion protein - ag8464 from Proteintech Group
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FMO2 fusion protein - Ag8610 from Proteintech Group
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Recombinant Human Dimethylaniline monooxygenase [N-oxide-forming] 2(FMO2) - CSB-YP857449HU CSB-EP857449HU CSB-BP857449HU CSB-MP857449HU from Cusabio
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FMO2 - TP303237 from Acris Antibodies
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Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) - RPC482Hu01 from Uscn Life Science Inc.
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Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) - RPC482Ra01 from Uscn Life Science Inc.
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Recombinant Flavin Containing Monooxygenase 2, Non Functional (FMO2) - RPC482Hu01 from Cloud-clone
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FMO2 Recombinant Protein Antigen - NBP1-85952PEP from Novus Biologicals
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FMO2-Antibody-C-term-Blocking-Peptide - BP6645b from Abgent, a WuXi AppTec company
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FMO2 Peptide, Human - M34GP05799H from Creative Peptides
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Flavin Containing Monooxygenase 2, Recombinant Protein - MBS2033184 from MyBioSource
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Flavin Containing Monooxygenase 2, Recombinant Protein - MBS2032944 from MyBioSource
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FMO2 Recombinant Protein (OPCD00596) - OPCD00596 from Aviva Systems Biology
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Dimethylaniline monooxygenase [N-oxide-forming] 2 (FMO2), Recombinant Protein - MBS1368677 from MyBioSource
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