| Gene Symbol |
FMO2
|
| Entrez Gene |
2327
|
| Alt Symbol |
FMO1B1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
flavin containing monooxygenase 2 (non-functional)
|
| Other Description |
FMO, pulmonary|dimethylaniline monooxygenase [N-oxide-forming] 2|dimethylaniline oxidase 2|pulmonary flavin-containing monooxygenase 2
|
| Swissprots |
Q9BRX1 Q86U73 Q5EBX4 Q99518
|
| Accessions |
AAW82431 EAW90889 Q99518 AI821378 AK098145 AK304385 BAG65221 AK312877 BAG35728 AL833218 CAI46191 BC005894 AAH05894 BI766311 BT006979 AAP35625 CA312067 DB224311 DB236882 DQ893533 ABM84459 DQ893748 ABM84674 R95468 Y09267 CAA70462 XR_426768 XR_921761 NM_001301347 NP_001288276 NM_001460 NP_001451
|
| Function |
Catalyzes the N-oxidation of certain primary alkylamines to their oximes via an N-hydroxylamine intermediate. Inactive toward certain tertiary amines, such as imipramine or chloropromazine. Can catalyze the S-oxidation of methimazole. The truncated form is catalytically inactive. {ECO:0000269|PubMed:9804831}.
|
| Subcellular Location |
Microsome membrane. Endoplasmic reticulum membrane.
|
| Tissue Specificity |
Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}.
|
| Top Pathways |
Drug metabolism - cytochrome P450
|