| Gene Symbol |
MICU2
|
| Entrez Gene |
221154
|
| Alt Symbol |
1110008L20Rik, EFHA1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondrial calcium uptake 2
|
| Other Description |
EF hand domain family A1|EF hand domain family, member A1|EF-hand domain family, member A1|EF-hand domain-containing family member A1|Smhs2 homolog|calcium uptake protein 2, mitochondrial
|
| Swissprots |
Q8N0T6 Q8IYU8 Q8NAX8
|
| Accessions |
EAX08312 EAX08313 Q8IYU8 AK057745 AK091907 BAC03769 BC031089 AAH31089 BC034965 AAH34965 BQ438851 JF432114 ADZ15331 JF432150 ADZ15367 XR_429214 NM_152726 NP_689939
|
| Function |
Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering. {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
|
| Subcellular Location |
Mitochondrion intermembrane space {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:24560927}.
|