MICU2

Gene Symbol	MICU2
Entrez Gene	221154
Alt Symbol	1110008L20Rik, EFHA1
Species	Human
Gene Type	protein-coding
Description	mitochondrial calcium uptake 2
Other Description	EF hand domain family A1|EF hand domain family, member A1|EF-hand domain family, member A1|EF-hand domain-containing family member A1|Smhs2 homolog|calcium uptake protein 2, mitochondrial
Swissprots	Q8N0T6 Q8IYU8 Q8NAX8
Accessions	EAX08312 EAX08313 Q8IYU8 AK057745 AK091907 BAC03769 BC031089 AAH31089 BC034965 AAH34965 BQ438851 JF432114 ADZ15331 JF432150 ADZ15367 XR_429214 NM_152726 NP_689939
Function	Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering. {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
Subcellular Location	Mitochondrion intermembrane space {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:24560927}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human EFHA1 protein fragment - ab127285 from Abcam Category Protein Source E. coli Species Human

EFHA1-Antibody-Center-Blocking-Peptide - BP8873c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EFHA1 fusion protein - Ag14830 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

EFHA1 fusion protein - ag14914 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human EFHA1, His-tagged - EFHA1-12305H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human EF-hand domain-containing family member A1(EFHA1) - CSB-YP818265HU CSB-EP818265HU CSB-BP818265HU CSB-MP818265HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

EFHA1 Recombinant Protein Antigen - NBP1-91864PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EFHA1 Peptide, Human - M34GP04747H from Creative Peptides Category Peptide Source Synthetic. Species Human

EFHA1 Recombinant Protein Antigen - NBP2-58050PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EF-hand domain-containing family member A1 (EFHA1), Recombinant Protein - MBS1355073 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,430.00, $1,430.00, $1,960.00, $1,960.00, $2,425.00, $2,425.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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