MICU2

Gene Symbol MICU2
Entrez Gene 221154
Alt Symbol 1110008L20Rik, EFHA1
Species Human
Gene Type protein-coding
Description mitochondrial calcium uptake 2
Other Description EF hand domain family A1|EF hand domain family, member A1|EF-hand domain family, member A1|EF-hand domain-containing family member A1|Smhs2 homolog|calcium uptake protein 2, mitochondrial
Swissprots Q8N0T6 Q8IYU8 Q8NAX8
Accessions EAX08312 EAX08313 Q8IYU8 AK057745 AK091907 BAC03769 BC031089 AAH31089 BC034965 AAH34965 BQ438851 JF432114 ADZ15331 JF432150 ADZ15367 XR_429214 NM_152726 NP_689939
Function Key regulator of mitochondrial calcium uniporter (MCU) required to limit calcium uptake by MCU when cytoplasmic calcium is low. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulate and inhibit MCU activity, respectively. MICU2 acts as a gatekeeper of MCU that senses calcium level via its EF-hand domains: prevents channel opening at resting Ca(2+), avoiding energy dissipation and cell-death triggering. {ECO:0000269|PubMed:24503055, ECO:0000269|PubMed:24560927}.
Subcellular Location Mitochondrion intermembrane space {ECO:0000269|PubMed:24231807, ECO:0000269|PubMed:24560927}.

EF-HA1 CRISPR/Cas9 KO Plasmid (h) - sc-407879 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 HDR Plasmid (h) - sc-407879-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 Double Nickase Plasmid (h) - sc-407879-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 Double Nickase Plasmid (h2) - sc-407879-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 CRISPR Activation Plasmid (h) - sc-407879-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 CRISPR Activation Plasmid (h2) - sc-407879-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 Lentiviral Activation Particles (h) - sc-407879-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 Lentiviral Activation Particles (h2) - sc-407879-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EF-HA1 siRNA (h) - sc-105321 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EF-HA1 shRNA Plasmid (h) - sc-105321-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EF-HA1 shRNA (h) Lentiviral Particles - sc-105321-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EFHA1 RNAi - H00221154-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU003011 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7687 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7687 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04642 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr04642

MICU2 siRNA (Human) - CRJ6494 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human EFHA1 (NM_152726.2) - SHH283537 from Creative biogene

Category siRNA
Species Reactivities Human

Human MICU2 siRNA - orb276995 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MICU2 shRNA Plasmid (Human) - CHJ6494 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

EFHA1 miRNA 3'UTR clone - MiUTR3H-11380 from Creative biogene

Species Reactivities Human
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